Tyrosinase

General Information (Source: NCBI Gene,UniProt)

Text mining Term Tyrosinase
UniProt ID PRPD3_DROME
Name Diphenol oxidase A3
Tyrosinase A3
Diphenoloxidase subunit A3
Gene Names
Taxonomy Drosophila melanogaster

General annotation

Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone (By similarity).
Subcellular location Secreted (By similarity). Note=Expression not detected in larval hemolymph.

Gene Ontology

GO:0046872 metal ion binding MF
GO:0005576 extracellular region CC
GO:0042438 melanin biosynthetic process BP
GO:0004503 monophenol monooxygenase activity MF
GO:0005344 oxygen transporter activity MF

Sequence

>gi|59798478|sp|Q9W1V6.1|PRPD3_DROME RecName: Full=Diphenoloxidase subunit A3; AltName: Full=Diphenol oxidase A3; AltName: Full=Tyrosinase A3; Flags: Precursor
MADKKNLLLLFDHPTEPVFMDKGGNGTVFDVPDSYVTDRYNQMCKKVQRRVSSASEKNVQVKEIAIPDLS
CSMRLGRSEQFSIFLKSHRKMASHLIEIFTKMQTVDELQSVAVYARDRVNPVLFNYALSVALLHRPDTKD
LELPAFAQTFPDRFIDSKMLRSMREESFVVERSAARLPVVSSVKYTASDLDVEHRLWYFREDLGVNLHHW
HWHLVYPIEAPDRSIVDKDRRGELFYYMHQQIIARYNAERLSNHMARVQPFNNLDEPIAEGYFPKMDSLV
ASRAYPPRFDNTRLSDVDRPNNQLRVGIDDMKRWRERIYEAIHQGYVLDTNNEKIVLDDAKGIDILGNII
EASDLTPNSTLYGDFHNMGHILIAYSHDPTNKHLEYAGVMGDASTAMRDPIFYKWHAFIDNMFQEHKRLL
SPYEKQELSFPDVRVESIQVESQGQVNRLTTFWQESDVDMSRGLDFVPRGHVLARFTHLQHHEFSYTIKV
ENSSEATRYGYVRIFLAPKLDDRNAPMLLEQQRLMMVELDKFVVTMPPGSHTITRNSTESSVTIPFERTF
RNLDKLEELQNFLCGCGWPQHMLIPKGRPEGLRFELFVMVSNYEEDKVDQTVADCGCSIAASYCGLRDRL
YPDRKSMGFPFDRKPRRGSEILENFLTPNMCAVEVIITHEDRTEKLREVPARS

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Database Cross Reference

Ensembl Gene
UniGene Dm.1829
PDB
RefSeq NP_524760.1
Pfam PF03722
PF00372
PF03723