NF kappa B

General Information (Source: NCBI Gene,UniProt)

Text mining Term NF kappa B
UniProt ID NFKB1_DROME
Name Nuclear factor NF-kappa-B p110 subunit
Nuclear factor NF-kappa-B p49 subunit
Rel-p68
Nuclear factor NF-kappa-B p68 subunit
Relish protein
Rel-p110
Rel-p49
Gene Names Rel
Taxonomy Drosophila melanogaster

General annotation

Function Plays a key role in the humoral immune response. Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes. I-kappa-B kinase complex (ird5 and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation.
Subcellular location Nuclear factor NF-kappa-B p68 subunit: Nucleus. Nuclear factor NF-kappa-B p110 subunit: Cytoplasm. Nuclear factor NF-kappa-B p49 subunit: Cytoplasm.

Gene Ontology

GO:0045944 positive regulation of transcription from RNA polymerase II promoter BP
GO:0006351 transcription, DNA-dependent BP
GO:0003700 sequence-specific DNA binding transcription factor activity MF
GO:0043565 sequence-specific DNA binding MF
GO:0048935 peripheral nervous system neuron development BP
GO:0045087 innate immune response BP
GO:0006967 positive regulation of antifungal peptide biosynthetic process BP
GO:0008063 Toll signaling pathway BP
GO:0050829 defense response to Gram-negative bacterium BP
GO:0005515 protein binding MF
GO:0005634 nucleus CC
GO:0005737 cytoplasm CC
GO:0045089 positive regulation of innate immune response BP
GO:0051607 defense response to virus BP
GO:0006964 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria BP
GO:0061057 peptidoglycan recognition protein signaling pathway BP
GO:0034198 cellular response to amino acid starvation BP
GO:0045429 positive regulation of nitric oxide biosynthetic process BP

Sequence

>gi|48428477|sp|Q94527.1|NFKB1_DROME RecName: Full=Nuclear factor NF-kappa-B p110 subunit; AltName: Full=Rel-p110; AltName: Full=Relish protein; Contains: RecName: Full=Nuclear factor NF-kappa-B p68 subunit; AltName: Full=Rel-p68; Contains: RecName: Full=Nuclear factor NF-kappa-B p49 subunit; AltName: Full=Rel-p49
MNMNQYYDLDNGKNVMFMNDASSTSGYSSSTSPNSTNRSFSPAHSPKTMELQTDFANLNLPGGNSPHQPP
MANSPYQNQLLNNGGICQLGATNLINSTGVSFGVANVTSFGNMYMDHQYFVPAPATVPPSQNFGYHQNGL
ASDGDIKHVPQLRIVEQPVEKFRFRYKSEMHGTHGSLNGANSKRTPKTFPEVTLCNYDGPAVIRCSLFQT
NLDSPHSHQLVVRKDDRDVCDPHDLHVSKERGYVAQFINMGIIHTAKKYIFEELCKKKQDRLVFQMNRRE
LSHKQLQELHQETEREAKDMNLNQVRLCFEAFKIEDNGAWVPLAPPVYSNAINNRKSAQTGELRIVRLSK
PTGGVMGNDELILLVEKVSKKNIKVRFFEEDEDGETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDRE
VNVYIELIRPSDDERSFPALPFRYKPRSVIVSRKRRRTGSSANSSSSGTESSNNSLDLPKTLGLAQPPNG
LPNLSQHDQTISEEFGREKHLNEFIASEDFRKLIEHNSSDLEKICQLDMGELQHDGHNRAEVPSHRNRTI
KCLDDLFEIYKQDRISPIKISHHKVEKWFIEHALNNYNRDTLLHEVISHKKDKLKLAIQTIQVMNYFNLK
DVVNSTLNADGDSALHVACQQDRAHYIRPLLGMGCNPNLKNNAGNTPLHVAVKEEHLSCVESFLNGVPTV
QLDLSLTNDDGLTPLHMAIRQNKYDVAKKLISYDRTSISVANTMDGNNALHMAVLEQSVELLVLILDAQN
ENLTDILQAQNAAGHTPLELAERKANDRVVQLLKNVYPEKGELAMTWIPCKVKEEIDSSSDESSDAGQLE
IKSEEMDIETKDEDSVELDLSSGPRRQKDESSRDTEMDNNKLQLLLKNKFIYDRLCSLLNQPLGHGSDPQ
DRKWMQLARQTHLKQFAFIWLGAEDLLDHVKRKGASVEFSTFARALQAVDPQAYALLVNPT

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.4154
PDB
RefSeq NP_996189.1
NP_477094.1
NP_996188.1
NP_996187.1
Pfam PF12796
PF00554
PF00023