Dicer

General Information (Source: NCBI Gene,UniProt)

Text mining Term Dicer
UniProt ID DCR1_SCHPO
Name ATP-dependent helicase dcr1
Cell cycle control protein dcr1
Endoribonuclease dcr1
RNA interference pathway protein dcr1
Protein Dicer
Gene Names dcr1
Taxonomy Schizosaccharomyces pombe 972h-

General annotation

Function Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Digests double-stranded RNA (dsRNA) producing 21 to 23 bp dsRNAs, so called interfering RNAs (siRNA). Required for both post-transcriptional and transcriptional gene silencing. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H3 'Lys-10' methylation necessary for centromere function. Required for recruitment of swi6 and cohesin to an ectopic dg repeat.
Subcellular location Cytoplasm. Nucleus.

Gene Ontology

GO:0051983 regulation of chromosome segregation BP
GO:0051570 regulation of histone H3-K9 methylation BP
GO:0090052 regulation of chromatin silencing at centromere BP
GO:0005829 cytosol CC
GO:0004386 helicase activity MF
GO:0007059 chromosome segregation BP
GO:0005524 ATP binding MF
GO:0035196 production of miRNAs involved in gene silencing by miRNA BP
GO:0003677 DNA binding MF
GO:0031048 chromatin silencing by small RNA BP
GO:0035389 establishment of chromatin silencing at silent mating-type cassette BP
GO:0004525 ribonuclease III activity MF
GO:0005720 nuclear heterochromatin CC
GO:0003723 RNA binding MF
GO:0030422 production of siRNA involved in RNA interference BP
GO:0007049 cell cycle BP
GO:0046872 metal ion binding MF
GO:0034613 cellular protein localization BP

Sequence

>gi|63054443|ref|NP_588215.2| dicer [Schizosaccharomyces pombe 972h-]
MDISSFLLPQLLRKYQQDVYNIASKQNTLLVMRTGAGKTLLAVKLIKQKLEEQILIQESNLEHKKISVFL
VNKVPLVFQQAEYIRSQLPAKVGMFYGELSIEMSEQLLTNIILKYNVIVITADLFYLFLARGFLSINDLN
LIIFDECHHAIGNDAYARIMNDFYHRAKAVLSKKHFTLPRIFGMTASPFTGKKGNLYHRLYQWEQLFDSK
AHVVSENELADYFCLPEESYVMYSNKLVVPPSDSIIKKCEETLQGCKLISRAVKTALAETIDMGLWFGEQ
VWLYLVDFVETKRLKKKALGKQLSDDEELAIDRLKIFVEDWKNNKYSDNGPRIPVFDSTDVTDKVFKLLE
LLKATYRKSDSVRTVIFVERKATAFTLSLFMKTLNLPNIRAHSFIGHGPSDQGEFSMTFRRQKDTLHKFK
TGKYNVLIATAVAEEGIDVPSCNLVIRFNICRTVTQYVQSRGRARAMASKFLIFLNTEELLIHERILHEE
KNLKFALSELSNSNIFDSLVCEERERVTDDIVYEVGETGALLTGLYAVSLLYNFCNTLSRDVYTRYYPTF
TAQPCLSGWYCFEVELPKACKVPAAQGSPAKSIRKAKQNAAFIMCLDLIRMGLIDKHLKPLDFRRKIADL
ETLEEDELKDEGYIETYERYVPKSWMKVPEDITRCFVSLLYTDANEGDNHIFHPLVFVQAHSFPKIDSFI
LNSTVGPRVKIVLETIEDSFKIDSHLLELLKKSTRYLLQFGLSTSLEQQIPTPYWLAPLNLSCTDYRFLE
NLIDVDTIQNFFKLPEPVQNVTDLQSDTVLLVNPQSIYEQYAFEGFVNSEFMIPAKKKDKAPSALCKKLP
LRLNYSLWGNRAKSIPKSQQVRSFYINDLYILPVSRHLKNSALLIPSILYHIENLLVASSFIEHFRLDCK
IDTACQALTSAESQLNFDYDRLEFYGDCFLKLGASITVFLKFPDTQEYQLHFNRKKIISNCNLYKVAIDC
ELPKYALSTPLEIRHWCPYGFQKSTSDKCRYAVLQKLSVKRIADMVEASIGACLLDSGLDSALKICKSLS
VGLLDISNWDEWNNYFDLNTYADSLRNVQFPYSSYIEETIGYSFKNKKLLHLAFIHPSMMSQQGIYENYQ
QLEFLGDAVLDYIIVQYLYKKYPNATSGELTDYKSFYVCNKSLSYIGFVLNLHKYIQHESAAMCDAIFEY
QELIEAFRETASENPWFWFEIDSPKFISDTLEAMICAIFLDSGFSLQSLQFVLPLFLNSLGDATHTKAKG
DIEHKVYQLLKDQGCEDFGTKCVIEEVKSSHKTLLNTELHLTKYYGFSFFRHGNIVAYGKSRKVANAKYI
MKQRLLKLLEDKSNLLLYSCNCKFSKKKPSDEQIKGDGKVKSLT

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene
PDB 2L6M
RefSeq NP_588215.2
Pfam PF04851
PF00636
PF00271
PF03368