NADPH cytochrome P450 reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term NADPH cytochrome P450 reductase
UniProt ID NCPR_SCHPO
Name P450R
NADPH--cytochrome P450 reductase
CPR
Gene Names ccr1
Taxonomy Schizosaccharomyces pombe 972h-

General annotation

Function This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Subcellular location Endoplasmic reticulum membrane; Single-pass membrane protein.

Gene Ontology

GO:0006696 ergosterol biosynthetic process BP
GO:0010181 FMN binding MF
GO:0005789 endoplasmic reticulum membrane CC
GO:0003958 NADPH-hemoprotein reductase activity MF
GO:0016021 integral to membrane CC
GO:0005506 iron ion binding MF

Sequence

>gi|19112838|ref|NP_596046.1| NADPH-cytochrome p450 reductase [Schizosaccharomyces pombe 972h-]
MKTYEYVLLVIILILSLCYFIYNNFLNKPKAPERRVVATDSIVELMEAEKLTAAVFFGSQTGTAEDFAYR
FSTEAKANFNLTNMVFDLENYDLTDLDNFDRSKLLVFFLATYGEGEPTDNAEAFLQLLEGDDTVFSSGKG
IEDTPFEGIRYAIFGLGNHTYEYYNAMAKKVDAAMTRLGATRVGNLGLGDDAAGMLEEDYLQWKDDTLPE
IGKLFHLQEVHKEYNPMFEVIEKPEISNTSSTVFLGEPSRQQLKGNVASKAPRSQANPFFSSPVRSLELF
KSGSRNCLHLELDIADSGMRYQTGDYASICPMNPSQAVDDLLEVLGLKEKRDTVIIVKPIDTLDKAPVLS
PTTYDTVFRYYYEICGIVSRQLLSFIAPFAPTPESKQELEKLGNDYDYFKKNVVDLHLNLAQVLRRVSPD
APFTKLPFSMLLENMAHMKPRYYSISSSSVVHPDKVHVTAVVDKKEWTDKNHIFYGLTTNYLLAHCRHMH
GEKIPHPNGLEYTLEGPRKNWTGKIPMFVKKSTFRLAPPDVPIIMVGPGTGVAPFRGFVMERANLASKGV
KVAKTLLFYGCQYSDKDFLYKEEWQQYKDVLKDSFELITAFSREQDHKIYVQHRLLEHSDTIAKLVEEGA
AFYICGDADHMAKDVVNALASILTTVDVDGMKAVKALRDDNRFFEDTW

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq NP_596046.1
Pfam PF00175
PF00667
PF00258