NADPH cytochrome P450 reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term NADPH cytochrome P450 reductase
UniProt ID NCPR_ASPNC
Name CPR
NADPH--cytochrome P450 reductase
P450R
Gene Names cprA
Taxonomy Aspergillus niger CBS 513.88

General annotation

Function This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis (By similarity).
Subcellular location Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Cell membrane; Single-pass membrane protein (By similarity). Microsome (By similarity).

Gene Ontology

GO:0005506 iron ion binding MF
GO:0003958 NADPH-hemoprotein reductase activity MF
GO:0016021 integral to membrane CC
GO:0005789 endoplasmic reticulum membrane CC
GO:0005886 plasma membrane CC
GO:0010181 FMN binding MF
GO:0005792 microsome CC
GO:0016126 sterol biosynthetic process BP

Sequence

>gi|145240509|ref|XP_001392901.1| NADPH--cytochrome P450 reductase [Aspergillus niger CBS 513.88]
MAQLDTLDLVVLAVLLVGSVAYFTKGTYWAVAKDPYASTGPAMNGAAKAGKTRNIIEKMEETGKNCVIFY
GSQTGTAEDYASRLAKEGSQRFGLKTMVADLEEYDYENLDQFPEDKVAFFVLATYGEGEPTDNAVEFYQF
FTGDDVAFESGASADEKPLSKLKYVAFGLGNNTYEHYNAMVRQVDAAFQKLGAQRIGSAGEGDDGAGTME
EDFLAWKEPMWAALSESMDLQEREAVYEPVFCVTENESLSPEDETVYLGEPTQSHLQGTPKGPYSAHNPF
IAPIAESRELFTVKDRNCLHMEISIAGSNLSYQTGDHIAVWPTNAGAEVDRFLQVFGLEGKRDSVINIKG
IDVTAKVPIPTPTTYDAAVRYYMEVCAPVSRQFVATLAAFAPDEESKAEIVRLGSDKDYFHEKVTNQCFN
IAQALQSITSKPFSAVPFSLLIEGITKLQPRYYSISSSSLVQKDKISITAVVESVRLPGASHMVKGVTTN
YLLALKQKQNGDPSPDPHGLTYSITGPRNKYDGIHVPVHVRHSNFKLPSDPSRPIIMVGPGTGVAPFRGF
IQERAALAAKGEKVGPTVLFFGCRKSDEDFLYKDEWKTYQDQLGDNLKIITAFSREGPQKVYVQHRLREH
SELVSDLLKQKATFYVCGDAANMAREVNLVLGQIIAAQRGLPAEKGEEMVKHMRSSGSYQEDVWS

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq XP_001392901.1
Pfam PF00667
PF00175
PF00258