Text mining Term | NADPH cytochrome P450 reductase |
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UniProt ID | NCPR_ASPNC |
Name |
P450R CPR NADPH--cytochrome P450 reductase |
Gene Names |
cprA
|
Taxonomy | Aspergillus niger CBS 513.88 |
Function |
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis (By similarity). |
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Subcellular location |
Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Cell membrane; Single-pass membrane protein (By similarity). Microsome (By similarity). |
GO:0010181 | FMN binding | MF |
GO:0005886 | plasma membrane | CC |
GO:0003958 | NADPH-hemoprotein reductase activity | MF |
GO:0016021 | integral to membrane | CC |
GO:0005506 | iron ion binding | MF |
GO:0005789 | endoplasmic reticulum membrane | CC |
GO:0005792 | microsome | CC |
GO:0016126 | sterol biosynthetic process | BP |
>gi|145240509|ref|XP_001392901.1| NADPH--cytochrome P450 reductase [Aspergillus niger CBS 513.88] MAQLDTLDLVVLAVLLVGSVAYFTKGTYWAVAKDPYASTGPAMNGAAKAGKTRNIIEKMEETGKNCVIFY GSQTGTAEDYASRLAKEGSQRFGLKTMVADLEEYDYENLDQFPEDKVAFFVLATYGEGEPTDNAVEFYQF FTGDDVAFESGASADEKPLSKLKYVAFGLGNNTYEHYNAMVRQVDAAFQKLGAQRIGSAGEGDDGAGTME EDFLAWKEPMWAALSESMDLQEREAVYEPVFCVTENESLSPEDETVYLGEPTQSHLQGTPKGPYSAHNPF IAPIAESRELFTVKDRNCLHMEISIAGSNLSYQTGDHIAVWPTNAGAEVDRFLQVFGLEGKRDSVINIKG IDVTAKVPIPTPTTYDAAVRYYMEVCAPVSRQFVATLAAFAPDEESKAEIVRLGSDKDYFHEKVTNQCFN IAQALQSITSKPFSAVPFSLLIEGITKLQPRYYSISSSSLVQKDKISITAVVESVRLPGASHMVKGVTTN YLLALKQKQNGDPSPDPHGLTYSITGPRNKYDGIHVPVHVRHSNFKLPSDPSRPIIMVGPGTGVAPFRGF IQERAALAAKGEKVGPTVLFFGCRKSDEDFLYKDEWKTYQDQLGDNLKIITAFSREGPQKVYVQHRLREH SELVSDLLKQKATFYVCGDAANMAREVNLVLGQIIAAQRGLPAEKGEEMVKHMRSSGSYQEDVWS |
Ensembl Gene | |
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UniGene | |
PDB | |
RefSeq |
XP_001392901.1 |
Pfam |
PF00175 PF00258 PF00667 |