lanosterol 14 alpha demethylase

General Information (Source: NCBI Gene,UniProt)

Text mining Term lanosterol 14 alpha demethylase
UniProt ID CP51_CANAL
Name Cytochrome P450-14DM
Sterol 14-alpha demethylase
Lanosterol 14-alpha demethylase
CYPLI
Cytochrome P450-LIA1
Cytochrome P450 51
Gene Names ERG11
Taxonomy Candida albicans SC5314

General annotation

Function Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Subcellular location Membrane (Potential).

Gene Ontology

GO:0001766 membrane raft polarization BP
GO:0005624 membrane fraction CC
GO:0005886 plasma membrane CC
GO:0042493 response to drug BP
GO:0016021 integral to membrane CC
GO:0008144 drug binding MF
GO:0008398 sterol 14-demethylase activity MF
GO:0006696 ergosterol biosynthetic process BP
GO:0020037 heme binding MF
GO:0009055 electron carrier activity MF

Sequence

>gi|68478280|ref|XP_716761.1| lanosterol 14-alpha -demethylase [Candida albicans SC5314]
MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAASYGQQPYE
FFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLM
EQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMR
RIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSL
LIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLND
LTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPE
DFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN
LRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKRETCMF

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq XP_716761.1
Pfam PF00067