O acetyltransferase

General Information (Source: NCBI Gene,UniProt)

Text mining Term O acetyltransferase
UniProt ID CLAT_DROME
Name Choline O-acetyltransferase 67 kDa chain
Choline acetylase
CHOACTase
Choline O-acetyltransferase 13 kDa chain
Choline O-acetyltransferase 54 kDa chain
ChAT
Choline O-acetyltransferase
Gene Names Cha
Taxonomy Drosophila melanogaster

General annotation

Function Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Subcellular location

Gene Ontology

GO:0004102 choline O-acetyltransferase activity MF
GO:0007274 neuromuscular synaptic transmission BP
GO:0005829 cytosol CC
GO:0008292 acetylcholine biosynthetic process BP
GO:0007399 nervous system development BP
GO:0005634 nucleus CC

Sequence

>gi|12644104|sp|P07668.3|CLAT_DROME RecName: Full=Choline O-acetyltransferase; Short=CHOACTase; Short=ChAT; Short=Choline acetylase; Contains: RecName: Full=Choline O-acetyltransferase 67 kDa chain; Contains: RecName: Full=Choline O-acetyltransferase 54 kDa chain; Contains: RecName: Full=Choline O-acetyltransferase 13 kDa chain
MASNEASTSAAGSGPESAALFSKLRSFSIGSGPNSPQRVVSNLRGFLTHRLSNITPSDTGWKDSILSIPK
KWLSTAESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYL
LDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVHDVAHFAARLLDGILSHREMLDSGE
LPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDRHVVVICRNQMYCVVLQASDR
GKLSESEIASQILYVLSDAPCLPAKPVPVGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLD
EPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHS
CSEGIAVVQLLEKIYKKIEEHPDEDNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVY
RYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAM
CQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGLREASIE
VTGEMHELFKDESYIISQCFLLSTSQVACSTDSFMGYGPVTPRGYGCSYNPHPEQIVFCVSAFYSCEDTS
ASRYAKSLQDSLDIMRDLLQN

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.1244
PDB
RefSeq NP_477004.5
NP_996239.2
Pfam PF00755