G protein

General Information (Source: NCBI Gene,UniProt)

Text mining Term G protein
UniProt ID RGS_DROME
Name RGS
Locomotion defects protein
Regulator of G-protein signaling loco
Loco
Gene Names loco
Taxonomy Drosophila melanogaster

General annotation

Function Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI and GAP activities on G(i) alpha subunits G-ialpha65A. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits. Involved in the dorsal-ventral axis formation of the egg. Acts as a G-protein signaling for glial cell differentiation during embryogenesis; G-ialpha65A, G-oalpha47A and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord. May be essential for nurse cell dumping during oogenesis. Required in neuroblast asymmetrical cell division. Plays a role in stress resistance and life span control.
Subcellular location Cytoplasm. Cell membrane. Apical cell membrane. Note=Recruited from the cytosol to the plasma membrane by the G(i) alpha subunit. Colocalizes with moody at the plasma membrane. Localizes as a crescent to the apical cortex in interphase and forms an apical crescent and segregates into the apical daughter cell at telophase. Colocalizes with G-ialpha65A and raps/pins at the apical cortex throughout mitosis.

Gene Ontology

GO:0016324 apical plasma membrane CC
GO:0005057 receptor signaling protein activity MF
GO:0055059 asymmetric neuroblast division BP
GO:0014045 establishment of endothelial blood-brain barrier BP
GO:0060857 establishment of glial blood-brain barrier BP
GO:0007186 G-protein coupled receptor signaling pathway BP
GO:0008069 dorsal/ventral axis specification, ovarian follicular epithelium BP
GO:0007049 cell cycle BP
GO:0019991 septate junction assembly BP
GO:0005096 GTPase activator activity MF
GO:0042594 response to starvation BP
GO:0045179 apical cortex CC
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway BP
GO:0007310 oocyte dorsal/ventral axis specification BP
GO:0032291 axon ensheathment in central nervous system BP
GO:0007419 ventral cord development BP
GO:0000578 embryonic axis specification BP
GO:0030866 cortical actin cytoskeleton organization BP
GO:0008105 asymmetric protein localization BP
GO:0009408 response to heat BP
GO:0006979 response to oxidative stress BP
GO:0001965 G-protein alpha-subunit binding MF
GO:0007303 cytoplasmic transport, nurse cell to oocyte BP
GO:0009786 regulation of asymmetric cell division BP
GO:0005092 GDP-dissociation inhibitor activity MF

Sequence

>gi|74947778|sp|Q9VCX1.2|RGS_DROME RecName: Full=Regulator of G-protein signaling loco; Short=RGS; AltName: Full=Locomotion defects protein; Short=Loco
MHHHHPPLPITGASGSTAVGTGAAAAEDASPAANSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNGIR
TVEVRRGYNGFGFTISGQQPCRLSCIISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSI
RMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLNPPEAVEPHKSKSSP
DHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCI
RKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEY
EPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRS
MYTMRILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISDRIL
VVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPNLLASFN
LIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLAL
ETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSH
CLLEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMNASDNDMYIK
TLMLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQT
FSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAA
PDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKKSAS
NAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCGQNSLSDLHSSRSS
LSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYPYYDIVFQGST
KSIDVQQPSQILAGKEVVIERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDT
QVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDELTNKVFNELLASKADAA
ASEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQAVADP
KKPIIAKLKAGVKLQVTERVAEHQDELLEGLKRAQLARLEDQRGTEINFDLPDFLKNKENLSAAVSKLRK
VRASLSPVSKVPATPTEIPQPAPRLSITRSQQPVSPMKVDQEPETDLPAATQDQTEFAKAPPPLPPKPKV
LPIKPSNWGVAQPTGNYCNKYSPSKQVPTSPKEASKPGTFASKIPLDLGRKSLEEAGSRCAYLDEPSSSF
V

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Database Cross Reference

Ensembl Gene
UniGene Dm.3231
PDB
RefSeq NP_732773.1
Pfam PF00615
PF00595
PF02196