COMT

General Information (Source: NCBI Gene,UniProt)

Text mining Term COMT
UniProt ID FOMT2_WHEAT
Name Caffeic acid 3-O-methyltransferase
TaOMT2
Flavone O-methyltransferase 2
Tricetin 3',4',5'-O-trimethyltransferase
TaCM
Gene Names OMT2
Taxonomy Triticum aestivum

General annotation

Function Flavonoid B-ring-specific O-methyltransferase with a preference for flavones > dihydroflavones > flavonols that possess at least two B-ring hydroxyl groups. Active with tricetin, 5- hydroxyferulic acid, luteolin, quercitin, eriodictyol, quercetagetin, taxifolin, gossypetin and myricetin. No activity with naringenin, apigenin, kaempferol, 7,8-dihydroxy- or 5,7,8- trihydroxy flavones, chlorogenic acid, gallic acid or daphnetin. Catalyzes the sequential O-methylation of tricetin via 3'-O- methyltricetin, 3',5'-O-methyltricetin to 3',4',5'-O- trimethyltricetin. May also be involved in S lignin biosynthesis.
Subcellular location

Gene Ontology

GO:0008171 O-methyltransferase activity MF
GO:0046983 protein dimerization activity MF
GO:0009813 flavonoid biosynthetic process BP
GO:0009809 lignin biosynthetic process BP

Sequence

>gi|145321007|gb|ABP63535.1| caffeic acid 3-O-methyltransferase [Triticum aestivum]
MGSIAAGADEDACMYALQLVSSSILPMTLKNAIELGLLETLMAAGGKFLTPAEVAAKLPSAANPEAPDMV
DRMLRLLASYNVVSCRTEEGKDGRLSRRYGAAPVCKYLTPNEDGVSMSALALMNQDKVLMESWYYLKDAV
LDGGIPFNKAYGMSAFEYHGTDPRFNRVFNEGMKNHSIIITKKLLESYKGFEGLGTLVDVGGGVGATVAA
ITAHYPTIKGINFDLPHVISEAPPFPGVTHVGGDMFQKVPSADAILMKWILHDWSDEHCATLLKNCYDAL
PAHGKVVLVECILPVNPEATPKAQGVFHVDMIMLAHNPGGRERYEREFEALAKGAGFAAMKTTYIYANAW
AIEFTK

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Database Cross Reference

Ensembl Gene
UniGene Ta.4350
PDB
RefSeq
Pfam PF08100
PF00891