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pyrethrins

Identification (Source:EPA,EU)

ID	1331
Name	pyrethrins
CAS	8003-34-7
IUPAC
Inchi
CIPAC	32
EPA Code	069002
Formula	C19H26O3
SMILES	O([C@]1([H])C(C([H])([H])[H])=C(C([H])([H])\C([H])=C([H])\C([H])=C([H])[H])C(C1([H])[H])=O)C([C@]([H])([C@@]2([H])\C([H])=C(\C(=O)OC([H])([H])[H])/C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])=O
Status	Approved

Classification

Mode of Action	Contact acting neurotoxins with repellent properties. Sodium channel modulator.
Pesticide Type	Insecticide, Acaricide, Veterinary treatment
Chemical Group	Plant derived
Classification	botanical insecticides

Properties (Source:PubChem)

Molecular Weight	328.4
Physical State	Viscous brown resin
AlogP	3.88
H-Bond Donor	0
H-Bond Acceptor	5
Surface Area	390.48
Polar Surface Area	69.67

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	320 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.00014 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.025 mg l-1
Birds	Acute		LD50	5620 mg kg-1
Birds	Acute		LD50	5620 mg kg-1
Earthworms	Acute	14 day	LD50	1000 mg kg-1
Fish	Acute	96 hour	LC50	0.032 mg l-1
Honeybees	Acute	48 hour	LD50	0.15 μg bee-1
Mammals	Acute oral		LD50	200 mg kg-1
Mammals	Acute oral		LD50	200 mg kg-1

Related targets

Target Name	RScore (About this table)
ScFvs	95(1,1,3,5)	Details
CYP2B	53(0,1,4,8)	Details
peroxisome proliferator activated receptor	41(0,1,2,6)	Details
thyroid stimulating hormone (protein family or complex)	32(0,1,1,2)	Details
sodium channel (protein family or complex)	208(0,0,1,203)	Details
cytochrome P450 (protein family or complex)	106(0,0,4,86)	Details
Acetylcholinesterase	96(0,0,0,96)	Details
glutathione S transferase	55(0,0,0,55)	Details
CYP3A4	26(0,0,3,11)	Details
ATPase	21(0,0,0,21)	Details
catalase	20(0,0,0,20)	Details
cholinesterase	19(0,0,0,19)	Details
C18	19(0,0,0,19)	Details
superoxide dismutase	19(0,0,0,19)	Details
cytochrome P450 monooxygenases	18(0,0,0,18)	Details
c fos	17(0,0,0,17)	Details
cytochrome c	17(0,0,0,17)	Details
cis 3	16(0,0,0,16)	Details
alkaline phosphatase	16(0,0,0,16)	Details
calcineurin (protein family or complex)	15(0,0,0,15)	Details
estrogen receptor	14(0,0,0,14)	Details
TESS	14(0,0,2,4)	Details
brain derived neurotrophic factor	14(0,0,0,14)	Details
calmodulin	13(0,0,0,13)	Details
Cl 2	13(0,0,0,13)	Details
lactate dehydrogenase (protein family or complex)	13(0,0,0,13)	Details
hCE 1	12(0,0,0,12)	Details
tyrosine hydroxylase	12(0,0,0,12)	Details
CYP1A1	12(0,0,0,12)	Details
P450scc	11(0,0,0,11)	Details
G6PD	10(0,0,0,10)	Details
androgen receptor	10(0,0,0,10)	Details
NMDA receptor (protein family or complex)	10(0,0,0,10)	Details
Ca v	9(0,0,0,9)	Details
hemoglobin (protein family or complex)	9(0,0,0,9)	Details
caspase 3	9(0,0,0,9)	Details
aspartate aminotransferase	9(0,0,0,9)	Details
hCE 2	9(0,0,0,9)	Details
CYP2B6	8(0,0,1,3)	Details
interleukin 1beta	8(0,0,0,8)	Details
PP1	8(0,0,0,8)	Details
carboxylesterase 1	8(0,0,0,8)	Details
follicle stimulating hormone (protein family or complex)	8(0,0,0,8)	Details
chitinase	8(0,0,0,8)	Details
60S ribosomal protein L22	7(0,0,0,7)	Details
WNT10B	7(0,0,0,7)	Details
fibronectin	7(0,0,0,7)	Details
acid phosphatases	7(0,0,0,7)	Details
alanine aminotransferase	7(0,0,0,7)	Details
glutathione reductase	7(0,0,0,7)	Details
CA1	7(0,0,0,7)	Details
ribosomal protein L39	7(0,0,0,7)	Details
glutamyl transpeptidase	7(0,0,0,7)	Details
chloride channel (protein family or complex)	6(0,0,0,6)	Details
transferase	6(0,0,0,6)	Details
glucose 6 phosphate dehydrogenase	6(0,0,0,6)	Details
P glycoprotein	6(0,0,0,6)	Details
ace 1	6(0,0,0,6)	Details
Paraoxonase	6(0,0,0,6)	Details
G protein	6(0,0,0,6)	Details
integrin	6(0,0,0,6)	Details
Nerve growth factor	6(0,0,0,6)	Details
F12	6(0,0,0,6)	Details
PHGPx	6(0,0,0,6)	Details
Nav1.4	6(0,0,0,6)	Details
NTCP	6(0,0,0,6)	Details
Cytochrome c oxidase (protein family or complex)	5(0,0,0,5)	Details
c jun	5(0,0,0,5)	Details
NF E2 related factor 2	5(0,0,0,5)	Details
RPS4	5(0,0,0,5)	Details
CASA	5(0,0,0,5)	Details
protein phosphatases	5(0,0,0,5)	Details
cAMP dependent protein kinase (protein family or complex)	5(0,0,0,5)	Details
mitogen activated protein kinase (protein family or complex)	4(0,0,0,4)	Details
dopamine transporter	4(0,0,0,4)	Details
succinate dehydrogenase (protein family or complex)	4(0,0,0,4)	Details
Ho 1	4(0,0,0,4)	Details
Koc	4(0,0,0,4)	Details
PC3	4(0,0,0,4)	Details
gamma glutamylcysteine synthetase	4(0,0,0,4)	Details
ribosomal protein (protein family or complex)	4(0,0,0,4)	Details
F18	4(0,0,0,4)	Details
Salvador	4(0,0,0,4)	Details
DR1	4(0,0,0,4)	Details
bcl 2	4(0,0,0,4)	Details
CD4	4(0,0,0,4)	Details
glutathione transferase	4(0,0,0,4)	Details
Hsp70	4(0,0,0,4)	Details
protein kinase C (protein family or complex)	4(0,0,0,4)	Details
albumin	4(0,0,0,4)	Details
gamma aminobutyric acid receptor (protein family or complex)	4(0,0,0,4)	Details
beta adrenergic receptors (protein family or complex)	4(0,0,0,4)	Details

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