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endosulfan

Identification (Source:EPA,EU)

ID	182
Name	endosulfan
CAS	115-29-7
IUPAC
Inchi	InChI=1S/C9H6Cl6O3S/c10-5-6(11)8(13)4-2-18-19(16)17-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2
CIPAC	89
EPA Code	079401
Formula	C9H6Cl6O3S
SMILES	Cl\C1=C(/Cl)C3(Cl)C(Cl)(Cl)C1(Cl)C2C3COS(=O)OC2
Status	Not Approved

Classification

Mode of Action	Non-systemic with contact and stomach action, acts as a non-competitive GABA antagonist
Pesticide Type	Insecticide, Acaricide
Chemical Group	Organochlorine (isomer mix)
Classification	cyclodiene insecticides organochlorine acaricides

Properties (Source:PubChem)

Molecular Weight	406.93
Physical State	Colourless to brown coloured crystals
AlogP	2.641
H-Bond Donor	0
H-Bond Acceptor	3
Surface Area	304.29
Polar Surface Area	54.74

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	2.15 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.24 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.44 mg l-1
Birds	Acute		LD50	111 mg kg-1
Earthworms	Acute	14 day	LD50	14 mg kg-1
Fish	Acute	96 hour	LC50	0.002 mg l-1
Fish	Chronic	21 day	NOEC	0.0000001 mg l-1
Honeybees	Acute	48 hour	LD50	7.81 μg bee-1
Mammals	Acute oral		LD50	38 mg kg-1
Mammals	Short term dietary		NOEL	15 ppm diet
Sediment dwelling organisms	Acute	96 hour	LC50	0.1 mg l-1
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	2755

Related targets

Target Name	RScore (About this table)
CS5	398(4,6,8,8)	Details
cytochrome P450 3A4	382(3,7,9,12)	Details
CYP2B6	380(3,7,9,10)	Details
C18	301(3,4,5,26)	Details
calmodulin	247(3,3,3,7)	Details
estrogen receptors	459(2,9,12,74)	Details
mMDH	305(2,6,8,15)	Details
ERK1	287(2,6,6,7)	Details
lactate dehydrogenase (protein family or complex)	222(2,3,7,12)	Details
cytochrome c	217(2,3,7,7)	Details
Connexin 43	206(2,3,5,6)	Details
P glycoprotein	190(2,2,3,25)	Details
chloride channel (protein family or complex)	179(2,2,2,19)	Details
progesterone receptor	173(2,2,2,13)	Details
CYP3A5	162(2,2,2,2)	Details
ATPase	317(1,7,12,32)	Details
cytochrome P450 (protein family or complex)	282(1,6,13,17)	Details
catalase	258(1,5,12,23)	Details
Acetylcholinesterase	233(1,3,14,38)	Details
malate dehydrogenase	136(1,2,6,6)	Details
ATPases	127(1,2,4,7)	Details
GABA receptor (protein family or complex)	109(1,1,2,24)	Details
immunoglobulin (protein family or complex)	94(1,1,3,4)	Details
estrogen receptor 2	92(1,1,1,12)	Details
glycine receptor (protein family or complex)	89(1,1,1,9)	Details
beta is	82(1,1,1,2)	Details
IL 6	82(1,1,1,2)	Details
sulfatase	82(1,1,1,2)	Details
GABA at	81(1,1,1,1)	Details
Telomerase (protein family or complex)	81(1,1,1,1)	Details
IL 1beta	81(1,1,1,1)	Details
glutathione S transferase	124(0,2,11,19)	Details
superoxide dismutase	102(0,2,8,12)	Details
alkaline phosphatase	94(0,2,6,14)	Details
demethylase	94(0,2,7,9)	Details
glutamyl transpeptidase	60(0,1,5,10)	Details
transferase	53(0,1,3,13)	Details
cholinesterase	48(0,1,2,13)	Details
hemoglobin (protein family or complex)	47(0,1,3,7)	Details
mitogen activated protein kinase (protein family or complex)	46(0,1,3,6)	Details
glucose 6 phosphate dehydrogenase	46(0,1,3,6)	Details
TERT	44(0,1,3,4)	Details
acid phosphatase	40(0,1,2,5)	Details
sorbitol dehydrogenase	37(0,1,2,2)	Details
sucrase	37(0,1,2,2)	Details
glutathione reductase	35(0,1,1,5)	Details
apoptosis related proteins	31(0,1,1,1)	Details
3 beta hydroxysteroid dehydrogenase	31(0,1,1,1)	Details
MC7	31(0,1,1,1)	Details
3 beta HSD	31(0,1,1,1)	Details
complex is	31(0,1,1,1)	Details
U82	31(0,1,1,1)	Details
17 beta hydroxysteroid dehydrogenase	31(0,1,1,1)	Details
pg m	54(0,0,7,19)	Details
muscles	42(0,0,6,12)	Details

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