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imazalil

Identification (Source:EPA,EU)

ID	522
Name	imazalil
CAS	35554-44-0
IUPAC
Inchi	InChI=1S/C14H14Cl2N2O/c1-2-7-19-14(9-18-6-5-17-10-18)12-4-3-11(15)8-13(12)16/h2-6,8,10,14H,1,7,9H2
CIPAC	335
EPA Code	111901
Formula	C14H14Cl2N2O
SMILES	Clc1ccc(c(Cl)c1)C(OC\C=C)Cn2ccnc2
Status	Approved

Classification

Mode of Action	Systemic with curative and protective properties. Disrupts membrane function.
Pesticide Type	Fungicide, Veterinary treatment
Chemical Group	Imidazole
Classification	conazole fungicides (imidazoles)

Properties (Source:PubChem)

Molecular Weight	297.18
Physical State	Yellow-brown oily solid
AlogP	3.349
H-Bond Donor	0
H-Bond Acceptor	2
Surface Area	281.76
Polar Surface Area	27.05

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Acute	72 hour	EC50, growth	0.87 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	3.5 mg l-1
Birds	Acute		LD50	510 mg kg-1
Birds	Short term dietary		LC50/LD50	> 5620 mg/kg feed
Earthworms	Acute	14 day	LD50	541 mg kg-1
Fish	Acute	96 hour	LC50	1.48 mg l-1
Fish	Chronic	21 day	NOEC	0.043 mg l-1
Honeybees	Acute	48 hour	LD50	35.1 μg bee-1
Mammals	Acute oral		LD50	227 mg kg-1
Mammals	Short term dietary		NOEL	2.5 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	0.181 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	165.4 mg kg-1
	Bio-concentration factor		BCF	56.3
	Bio-concentration factor		CT50	35.2 days

Related targets

Target Name	RScore (About this table)
cytochrome P450 (protein family or complex)	257(3,3,5,7)	Details
cytochrome P450 3A4	85(1,1,1,5)	Details
CYP1A1	83(1,1,1,3)	Details
demethylase	82(1,1,1,2)	Details
peroxisome proliferator activated receptor	41(0,1,2,6)	Details
CYP2B	32(0,1,1,2)	Details
angiotensin II	32(0,1,1,2)	Details
BP22	31(0,1,1,1)	Details

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