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propiconazole

Identification (Source:EPA,EU)

ID	546
Name	propiconazole
CAS	60207-90-1
IUPAC
Inchi	InChI=1S/C15H17Cl2N3O2/c1-2-3-12-7-21-15(22-12,8-20-10-18-9-19-20)13-5-4-11(16)6-14(13)17/h4-6,9-10,12H,2-3,7-8H2,1H3
CIPAC	408
EPA Code	122101
Formula	C15H17Cl2N3O2
SMILES	Clc1ccc(c(Cl)c1)C2(OCC(O2)CCC)Cn3ncnc3
Status	Approved

Classification

Mode of Action	Systemic with curative and protective action, works via the demethylation of C-14 during ergosterol biosynthesis
Pesticide Type	Fungicide
Chemical Group	Triazole
Classification	conazole fungicides (triazoles)

Properties (Source:PubChem)

Molecular Weight	342.22
Physical State	Yellow viscous liquid
AlogP	3.8
H-Bond Donor	0
H-Bond Acceptor	4
Surface Area	314.05
Polar Surface Area	49.17

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Chronic	96 hour	NOEC, growth	0.32 mg l-1
Algae	Acute	72 hour	EC50, growth	0.23 mg l-1
Aquatic crustaceans	Acute	96 hour	LC50	0.37 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.31 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	10.2 mg l-1
Aquatic plants	Acute	7 day	EC50, biomass	4.9 mg l-1
Birds	Acute		LD50	> 2510 mg kg-1
Birds	Short term dietary		LC50/LD50	> 5620 mg/kg feed
Earthworms	Acute	14 day	LD50	686 mg kg-1
Fish	Chronic	21 day	NOEC	0.068 mg l-1
Fish	Acute	96 hour	LC50	2.6 mg l-1
Honeybees	Acute	48 hour	LD50	> 100 μg bee-1
Mammals	Acute oral		LD50	958 mg kg-1
Mammals	Short term dietary		NOEL	20 ppm diet
Mammals	Short term dietary		NOEL	2.7 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	25.0 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	8.0 mg kg-1
	Bio-concentration factor		BCF	116
	Bio-concentration factor		CT50	8 days

Related targets

Target Name	RScore (About this table)
cytochrome P450 (protein family or complex)	328(2,6,10,28)	Details
glutathione S transferase	48(0,1,3,8)	Details
cis 4	37(0,1,2,2)	Details
HSD1	31(0,1,1,1)	Details
protein as	31(0,1,1,1)	Details
CYP51	17(0,0,2,7)	Details
CYP1A2	13(0,0,2,3)	Details
cytochrome P450 3A4	11(0,0,1,6)	Details
catalase	10(0,0,1,5)	Details
demethylase	8(0,0,0,8)	Details
apoprotein	8(0,0,1,3)	Details
superoxide dismutase	7(0,0,1,2)	Details
keratin (protein family or complex)	7(0,0,1,2)	Details
Koc	6(0,0,1,1)	Details
CYP2B	6(0,0,1,1)	Details
EGFR	6(0,0,1,1)	Details
Cyp26a1	6(0,0,1,1)	Details
beta catenin	6(0,0,1,1)	Details
PTEN	6(0,0,1,1)	Details
microRNA	5(0,0,0,5)	Details
pregnane X receptor	5(0,0,0,5)	Details
C18	5(0,0,0,5)	Details

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