---

nitrofen

Identification (Source:EPA,EU)

ID	946
Name	nitrofen
CAS	1836-75-5
IUPAC	2,4-dichlorophenyl 4-nitrophenyl ether
Inchi	InChI=1S/C12H7Cl2NO3/c13-8-1-6-12(11(14)7-8)18-10-4-2-9(3-5-10)15(16)17/h1-7H
CIPAC
EPA Code	038201
Formula	C12H7Cl2NO3
SMILES	c1(Oc2ccc([N+](=O)[O-])cc2)c(cc(Cl)cc1)Cl
Status	Not Approved

Classification

Mode of Action	Contact action, inhibits noncyclic electron transport distrupting photosynthesis
Pesticide Type	Herbicide
Chemical Group	Diphenyl ether
Classification	nitrophenyl ether herbicides

Properties (Source:PubChem)

Molecular Weight	284.1
Physical State	Colourless, crystalline solid
AlogP	4.613
H-Bond Donor	0
H-Bond Acceptor	3
Surface Area	249.9
Polar Surface Area	55.05

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Aquatic invertebrates	Acute	48 hour	EC50	40.0 mg l-1
Fish	Acute	96 hour	LC50	7.0 mg l-1
Mammals	Acute oral		LD50	2630 mg kg-1

Related targets

Target Name	RScore (About this table)
Retinal dehydrogenase 2	280(3,4,4,10)	Details
vascular endothelial growth factor	306(3,3,10,31)	Details
p38	232(2,4,5,7)	Details
aquaporin 5	219(2,3,6,14)	Details
MAPK (protein family or complex)	199(2,3,3,9)	Details
BMP4	196(2,3,3,6)	Details
surfactant protein	260(2,2,13,45)	Details
estrogen receptor alpha	167(2,2,2,7)	Details
proliferating cell nuclear antigen	167(2,2,2,7)	Details
P19	181(1,4,5,6)	Details
ET A	139(1,2,5,14)	Details
angiotensin I	130(1,2,4,10)	Details
Atrial natriuretic peptide	121(1,2,3,6)	Details
Hoxb 5	116(1,2,2,6)	Details
Connexin 43	146(1,1,10,21)	Details
tropoelastin	131(1,1,4,36)	Details
Thyroid transcription factor 1	130(1,1,7,20)	Details
ICAM 1	112(1,1,4,17)	Details
epidermal growth factor	99(1,1,3,9)	Details
thyroid hormone receptor (protein family or complex)	94(1,1,2,9)	Details
sulfotransferase	89(1,1,1,9)	Details
sulfotransferases (protein family or complex)	87(1,1,2,2)	Details
MEF2C	83(1,1,1,3)	Details
protoporphyrinogen oxidase	82(1,1,1,2)	Details
apoprotein	81(1,1,1,1)	Details
NAT1	81(1,1,1,1)	Details
T3 receptor	81(1,1,1,1)	Details
phosphodiesterases (protein family or complex)	81(1,1,1,1)	Details
NAT2	81(1,1,1,1)	Details
GATA6	140(0,4,6,10)	Details
GATA4	119(0,3,6,14)	Details
caspase 3	64(0,2,2,4)	Details
calcitonin gene related peptide	66(0,1,4,21)	Details
insulin like growth factor binding protein 3	51(0,1,4,6)	Details
LRAT	45(0,1,3,5)	Details
IGFBP 5	45(0,1,3,5)	Details
EGFR	41(0,1,2,6)	Details
casein	39(0,1,2,4)	Details
Cyp26b1	38(0,1,2,3)	Details
SULT1A1	37(0,1,2,2)	Details
tumor necrosis factor alpha	34(0,1,1,4)	Details
serine threonine protein kinase	32(0,1,1,2)	Details
lactate dehydrogenase (protein family or complex)	31(0,1,1,1)	Details
ATPase	31(0,1,1,1)	Details
neutral endopeptidase	31(0,1,1,1)	Details
caspase (protein family or complex)	31(0,1,1,1)	Details
SP B	77(0,0,9,32)	Details
COUP TFII	38(0,0,5,13)	Details
IL 6	36(0,0,4,16)	Details
Ghrelin	29(0,0,4,9)	Details
ttf 1	28(0,0,4,8)	Details
ET B	26(0,0,3,11)	Details

Docunmentation of Network Visuallization