| Name | vitamin K epoxide reductase |
|---|---|
| Synonyms | Vitamin K epoxide reductase; IMAGE3455200; MST134; MST576; MSTP134; MSTP576; Phylloquinone epoxide reductase; UNQ308… |
| Name | chlorophacinone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19752778 | Grandemange A, Kohn MH, Lasseur R, Longin-Sauvageon C, Berny P, Benoit E: Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats. Pharmacogenet Genomics. 2009 Oct;19(10):742-50. RESULTS AND CONCLUSION: In this manuscript we report the prothrombin times measured in the F7 generation after exposure to chlorophacinone, bromadiolone, difenacoum and difethialone. |
6(0,0,0,6) | Details |
| 15879509 | Pelz HJ, Rost S, Hunerberg M, Fregin A, Heiberg AC, Baert K, MacNicoll AD, Prescott CV, Walker AS, Oldenburg J, Muller CR: The genetic basis of resistance to anticoagulants in rodents. Genetics. 2005 Aug;170(4):1839-47. Epub 2005 May 6. Anticoagulant compounds, i.e., derivatives of either (e.g., bromadiolone) or indane-1,3-dione (e.g., diphacinone, chlorophacinone), have been in worldwide use as rodenticides for > 50 years. These compounds inhibit blood coagulation by repression of the vitamin K reductase reaction (VKOR). |
4(0,0,0,4) | Details |
| 16506805 | Lawley WJ, Charlton AJ, Hughson EJ, Grundy HH, Brown PM, Jones A: Development of a cell culture/ELISA assay to detect anticoagulant rodenticides and its application to analysis of rodenticide treated grain. J Agric Food Chem. 2006 Mar 8;54(5):1588-93. This study describes a generic biological screening assay designed to detect anticoagulant rodenticides based on their inhibitory action on the vitamin K epoxide reductase protein complex, resulting in an accumulation of under-carboxylated prothrombin or proteins induced by antagonism (PIVKA-II). |
1(0,0,0,1) | Details |