| Name | PP2A |
|---|---|
| Synonyms | PP2A; PP2A subunit B prime; PR53; PTPA; Phosphotyrosyl phosphatase activator; Serine/threonine protein phosphatase 2A regulatory subunit B'; PP2A subunit B primes… |
| Name | endothal |
|---|---|
| CAS | 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8924598 | Mahajna M, Quistad GB, Casida JE: Retro-Diels-Alder reaction: possible involvement in the metabolic activation of 7-oxabicyclo [2.2.1] hepta-2 (3),5 (6)-diene-2,3-dicarboxylates and a phosphonate analog. Chem Res Toxicol. 1996 Jan-Feb;9(1):241-6. The toxicity of the herbicide endothal (exo,exo-7-oxabicyclo [2.2.1] heptane-2,3-dicarboxylic acid) to mice (ip LD50 = 14 mg/kg) is attributed to the inhibition of protein phosphatase 2A (PP2A) at the cantharidin binding site. |
31(0,1,1,1) | Details |
| 10658599 | Laidley CW, Dauben WG, Guo ZR, Lam JY, Casida JE: 2-Carboxymethylendothal analogues as affinity probes for stabilized protein phosphatase 2A. Bioorg Med Chem. 1999 Dec;7(12):2937-44. Endothal (1diacid) and [3H] cantharidic acid ([3H] CA) bind with high affinity to the catalytic subunit of protein phosphatase 2A (PP2A). |
62(0,2,2,2) | Details |