Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name kinetin
CAS

Reference List

PubMed Abstract RScore(About this table)
12147295 Xue L, Borutaite V, Tolkovsky AM: Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues. Biochem Pharmacol. 2002 Aug 1;64(3):441-9.

4(0,0,0,4) Details
16113211 Welchen E, Gonzalez DH: Differential expression of the Arabidopsis cytochrome c genes Cytc-1 and Cytc-2. Plant Physiol. 2005 Sep;139(1):88-100. Epub 2005 Aug 19.

3(0,0,0,3) Details
10871858 Edamatsu H, Gau CL, Nemoto T, Guo L, Tamanoi F: Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Oncogene. 2000 Jun 22;19(27):3059-68.


This involves changes in mitochondria, including decrease of mitochondrial membrane potential and the release of cytochrome c.
3(0,0,0,3) Details
12520332 Carimi F, Zottini M, Formentin E, Terzi M, Lo Schiavo F: Cytokinins: new apoptotic inducers in plants. Planta. 2003 Jan;216(3):413-21. Epub 2002 Sep 17.


In the present work, cell death was scored by Evan's blue staining and was also demonstrated to be programmed by various parameters, including chromatin condensation, oligonucleosomal DNA degradation (laddering), and release of cytochrome c from mitochondria.
1(0,0,0,1) Details
18162289 Choi BH, Kim W, Wang QC, Kim DC, Tan SN, Yong JW, Kim KT, Yoon HS: Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Lett. 2008 Mar 8;261(1):37-45. Epub 2007 Dec 26.

KR disrupted the mitochondrial membrane potential and induced the release of cytochrome c and activation of caspase-3.
1(0,0,0,1) Details
15827328 Jiang H, Zhang L, Kuo J, Kuo K, Gautam SC, Groc L, Rodriguez AI, Koubi D, Hunter TJ, Corcoran GB, Seidman MD, Levine RA: Resveratrol-induced apoptotic death in human U251 glioma cells. Mol Cancer Ther. 2005 Apr;4(4):554-61.


Resveratrol induces cytochrome c release from mitochondria to the cytoplasm and activation of caspase-9.
1(0,0,0,1) Details
16995912 Zottini M, Barizza E, Bastianelli F, Carimi F, Lo Schiavo F: Growth and senescence of Medicago truncatula cultured cells are associated with characteristic mitochondrial morphology. New Phytol. 2006;172(2):239-47.


The release of cytochrome c from mitochondria was detected in different growth phases of cultured cells.
1(0,0,0,1) Details
16660137 Tanaka Y, Uritani I: Polarity of Production of Polyphenols and Development of Various Enzyme Activities in Cut-injured Sweet Potato Root Tissue. Plant Physiol. 1977 Oct;60(4):563-566.

The similar polarity was observed in the development of activities of various enzymes, such as NADPH-cytochrome c oxidoreductase, acid invertase, peroxidase, o-diphenol oxidase, and cytochrome c-O (2) oxidoreductase.
Treatment of the distal surface of tissue pieces with IAA or 2,4-dichlorophenoxyacetic acid caused polyphenol production but treatment with gibberellic acid, abscisic acid, kinetin, or ethylene had little effect.
1(0,0,0,1) Details