Protein Information

Name PP1
Synonyms NPY4 R; PP1; NPY4R; Neuropeptide Y receptor type 4; PPYR 1; PPYR1; Pancreatic polypeptide receptor 1; Y4…

Compound Information

Name kinetin
CAS

Reference List

PubMed Abstract RScore(About this table)
12534346 Bain J, McLauchlan H, Elliott M, Cohen P: The specificities of protein kinase inhibitors: an update. Biochem J. 2003 Apr 1;371(Pt 1):199-204.


Kenpaullone, Alsterpaullone, Purvalanol, Roscovitine, pyrazolopyrimidine 1 (PP1), PP2 and ML-7 were more specific, but still inhibited two or more protein kinases with similar potency.
2(0,0,0,2) Details
10506210 Liu CW, Wang RH, Dohadwala M, Schonthal AH, Villa-Moruzzi E, Berndt N: Inhibitory phosphorylation of PP1alpha catalytic subunit during the G (1)/S transition. J Biol Chem. 1999 Oct 8;274(41):29470-5.


Inhibition of Cdk2 led to a small increase in PP1 activity and also prevented PP1alpha phosphorylation.
1(0,0,0,1) Details
8799831 Paulson JR, Patzlaff JS, Vallis AJ: Evidence that the endogenous histone H1 phosphatase in HeLa mitotic chromosomes is protein phosphatase 1, not protein phosphatase 2A. J Cell Sci. 1996 Jun;109 ( Pt 6):1437-47.


The concentrations of microcystin and okadaic acid required for inhibition strongly suggest that the histone H1 phosphatase is either PP1 or an unknown protein phosphatase with okadaic acid-sensitivity similar to PP1.
1(0,0,0,1) Details
15152189 Morfini G, Szebenyi G, Brown H, Pant HC, Pigino G, DeBoer S, Beffert U, Brady ST: A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons. EMBO J. 2004 Jun 2;23(11):2235-45. Epub 2004 May 20.


This pathway involves enzymatic activities of cyclin-dependent kinase 5 (CDK5), protein phosphatase 1 (PP1) and glycogen synthase kinase-3 (GSK3).
2(0,0,0,2) Details
16169145 Tamaki H, Sakuma T, Uchida Y, Jaruchotikamol A, Nemoto N: Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes. Toxicology. 2005 Dec 15;216(2-3):224-31. Epub 2005 Sep 15.


In contrast, the inhibitory expression was prolonged in the presence of okadaic acid, a potent inhibitor of serine/threonine phosphatase PP1 and PP2.
1(0,0,0,1) Details