Protein Information

Name MC1
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name mecoprop
CAS 2-(4-chloro-2-methylphenoxy)propanoic acid

Reference List

PubMed Abstract RScore(About this table)
10652787 Muller RH, Jorks S, Kleinsteuber S, Babel W: Comamonas acidovorans strain MC1: a new isolate capable of degrading the chiral herbicides dichlorprop and mecoprop and the herbicides 2,4-D and MCPA. Microbiol Res. 1999 Dec;154(3):241-6.
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11572451 Muller RH, Kleinsteuber S, Babel W: Physiological and genetic characteristics of two bacterial strains utilizing phenoxypropionate and phenoxyacetate herbicides. Microbiol Res. 2001;156(2):121-31.

P230 and Delftia (Comamonas) acidovorans MCI, have previously been shown to carry activities for the degradation of the two enantiomers of (RS)-2-(2,4-dichlorophenoxy-) propionate (dichlorprop) and (RS)-2-(4-chloro-2-methylphenoxy-) propionate (mecoprop) and, in addition, are capable of degrading phenoxyacetate derivatives 2.4-dichlorophenoxyacetate (2,4-D) and 4-chloro-2-methylphenoxyacetate (MCPA).
These activities were constitutively expressed for both enantiomers of dichlorprop in strain MC1 and for the Renantiomer in strain P230.
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9642189 Zipper C, Bunk M, Zehnder AJ, Kohler HP: Enantioselective uptake and degradation of the chiral herbicide dichlorprop [(RS)-2-(2,4-dichlorophenoxy) propanoic acid] by Sphingomonas herbicidovorans MH. J Bacteriol. 1998 Jul;180(13):3368-74.

Transport of (R)-dichlorprop, (S)-dichlorprop, and 2,4-D was completely inhibited by various uncouplers and by nigericin but was only marginally inhibited by valinomycin and by the ATPase inhibitor N,N'-dicyclohexylcarbodiimine.
These results are in agreement with the recently reported enantioselective degradation of mecoprop [(RS)-2-(4-chloro-2-methylphenoxy) propanoic acid] by this bacterium (C.
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15466552 Muller TA, Byrde SM, Werlen C, van der Meer JR, Kohler HP: Genetic analysis of phenoxyalkanoic acid degradation in Sphingomonas herbicidovorans MH. Appl Environ Microbiol. 2004 Oct;70(10):6066-75.


We report the isolation of several genes involved in dichlor- and mecoprop degradation from the alphaproteobacterium Sphingomonas herbicidovorans MH and propose that the degradation proceeds analogously to that previously reported for 2,4-dichlorophenoxyacetic acid (2,4-D).
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