| Name | Microsomal monooxygenase |
|---|---|
| Synonyms | ARO; Microsomal monooxygenase; Flavoprotein linked monooxygenase; ARO 1; ARO1; Aromatase; Aromatase cytochrome P450; CPV 1… |
| Name | methoxychlor |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-methoxybenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6857671 | Bulger WH, Temple JE, Kupfer D: Covalent binding of [14C] methoxychlor metabolite (s) to rat liver microsomal components. Toxicol Appl Pharmacol. 1983 May;68(3):367-74. It was concluded that methoxychlor undergoes a hepatic microsomal monooxygenase (s)-mediated activation and that the resultant reactive metabolites (possibly free radicals) bind covalently to microsomal components. |
31(0,1,1,1) | Details |
| 16996190 | Laville N, Balaguer P, Brion F, Hinfray N, Casellas C, Porcher JM, Ait-Aissa S: Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line. Toxicology. 2006 Nov 10;228(1):98-108. Epub 2006 Aug 24. To further investigate the mechanisms of aromatase induction we measured CYP19 mRNA expression and showed that methoxychlor, aldrin, chlordane and tributyltin induced the transcription of the cyp19 gene. |
6(0,0,1,1) | Details |
| 3965923 | Bulger WH, Feil VJ, Kupfer D: Role of hepatic monooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants. Mol Pharmacol. 1985 Jan;27(1):115-24. To examine these properties, we utilized an assay developed by us that monitors whether a given compound, incubated with isolated rat uteri, can diminish the uterine cytosolic estrogen receptor and elevate the nuclear estrogen receptor and whether metabolic intervention by hepatic microsomal monooxygenase (s) is required by the respective compound for this cellular redistribution of the receptor. |
1(0,0,0,1) | Details |