| Name | TRPA1 |
|---|---|
| Synonyms | ANKTM 1; ANKTM1; Ankyrin like protein with transmembrane domains 1; Ankyrin like with transmembrane domains protein 1; TRPA 1; TRPA1; Transformation sensitive protein p120; Transient receptor potential cation channel subfamily A member 1… |
| Name | formaldehyde |
|---|---|
| CAS | formaldehyde |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17942735 | Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B, Corey DP, Patapoutian A: An ion channel essential for sensing chemical damage. J Neurosci. 2007 Oct 17;27(42):11412-5. Here we show that formaldehyde activates the ion channel TRPA1 and that TRPA1-deficient mice exhibit dramatically reduced formaldehyde-induced pain responses. a reactive chemical produced endogenously during oxidative stress, and other related aldehydes also activate TRPA1 in vitro. |
82(1,1,1,2) | Details |
| 19383149 | Kerstein PC, del Camino D, Moran MM, Stucky CL: Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain. 2009 Apr 21;5:19. |
8(0,0,0,8) | Details |
| 17686976 | McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM: TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30. Epub 2007 Aug 8. |
6(0,0,0,6) | Details |
| 19059884 | Taylor-Clark TE, Kiros F, Carr MJ, McAlexander MA: Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation. Am J Respir Cell Mol Biol. 2009 Jun;40(6):756-62. Epub 2008 Dec 4. Recent studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1), an ion channel largely restricted to a subset of -sensitive sensory nerves, functions as a transducer capable of initiating reflex responses to many reactive chemical stimuli. |
4(0,0,0,4) | Details |
| 19847360 | Tian LJ, DU YR, Xiao Y, Lv ZM, Yu YQ, Cui XY, Chen J: Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde. Sheng Li Xue Bao. 2009 Oct 25;61(5):404-16. In comparison with controls, the FA-evoked inward current could be significantly suppressed by CPZ that was further enhanced by HC-030031, a TRPA1 selective antagonist. |
2(0,0,0,2) | Details |
| 18810801 | Reeh P: TRPA1-mediated nociception: response to letter by Fischer et al. Neuroscience. 2008 Aug 13;155(2):339; author reply 340. |
1(0,0,0,1) | Details |
| 17481391 | Dhaka A, Murray AN, Mathur J, Earley TJ, Petrus MJ, Patapoutian A: TRPM8 is required for cold sensation in mice. Neuron. 2007 May 3;54(3):371-8. TRPM8 and TRPA1 are both activated by cooling; however, it is unclear whether either ion channel is required for thermosensation in vivo. |
1(0,0,0,1) | Details |
| 18810800 | Fischer L, Tambeli CH, Parada CA: TRPA1-mediated nociception. Neuroscience. 2008 Aug 13;155(2):337-8. |
1(0,0,0,1) | Details |
| 19800272 | Bolcskei K, Tekus V, Dezsi L, Szolcsanyi J, Petho G: Antinociceptive desensitizing actions of TRPV1 receptor agonists resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat. Eur J Pain. 2009 Sep 30. The diminished acute nocifensive and heat threshold-lowering effects of resiniferatoxin or N-oleoyldopamine by pretreatment with doses that failed to elevate the heat threshold and to alter the nocifensive action of the TRPA1 activator formaldehyde, were taken as indication of TRPV1 receptor desensitization. |
0(0,0,0,0) | Details |