Protein Information

Name Substance P
Synonyms Hs.2563; PPT; NK2; NKA; NKNA; Neurokinin 1; Neurokinin 2; Neurokinin A…

Compound Information

Name formaldehyde
CAS formaldehyde

Reference List

PubMed Abstract RScore(About this table)
17418497 Wiley RG, Kline RH 4th, Vierck CJ Jr: Anti-nociceptive effects of selectively destroying substance P receptor-expressing dorsal horn neurons using [Sar9,Met (O2) 11]-substance P-saporin: behavioral and anatomical analyses. Neuroscience. 2007 May 25;146(3):1333-45. Epub 2007 Apr 5.

3(0,0,0,3) Details
19103267 Lu X, Geng X, Zhang L, Zeng Y, Dong H, Yu H: Substance P expression in the distal cerebrospinal fluid-contacting neurons and spinal trigeminal nucleus in formalin-induced the orofacial inflammatory pain in rats. Brain Res Bull. 2009 Mar 16;78(4-5):139-44. Epub 2008 Dec 25.

2(0,0,0,2) Details
18197882 Greco R, Tassorelli C, Sandrini G, Di Bella P, Buscone S, Nappi G: Role of calcitonin gene-related peptide and substance P in different models of pain. Cephalalgia. 2008 Feb;28(2):114-26.

2(0,0,0,2) Details
18846040 Nazarian A, Christianson CA, Hua XY, Yaksh TL: Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine. Br J Pharmacol. 2008 Dec;155(7):1117-26. Epub 2008 Sep 1.


This study addressed the subtype of spinal alpha (2)-adrenoceptor responsible for the analgesic effects of i.t. dexmedetomidine and ST-91 in the formalin behavioural model and their effects on primary afferent substance P (SP) release and spinal Fos activation.
2(0,0,0,2) Details
17568617 Sandor K, Helyes Z, Gyires K, Szolcsanyi J, Laszlo J: Static magnetic field-induced anti-nociceptive effect and the involvement of capsaicin-sensitive sensory nerves in this mechanism. Life Sci. 2007 Jun 20;81(2):97-102. Epub 2007 May 6.


Selective inactivation of capsaicin-sensitive sensory fibres by high dose resiniferatoxin pretreatment decreased nocifensive behaviours in phase II of the formalin test to a similar extent suggesting that pro-inflammatory neuropeptides such as substance P and calcitonin gene-related peptide released from these fibres are involved in this inflammatory reaction.
1(0,0,0,1) Details
18329177 Seo YJ, Kwon MS, Choi SS, Han EJ, Jung JS, Choi HW, Park SH, Jang JE, Suh HW: Characterization of the hypothalamic proopiomelanocortin gene and beta-endorphin expression in the hypothalamic arcuate nucleus of mice elicited by inflammatory pain. Neuroscience. 2008 Apr 9;152(4):1054-66. Epub 2007 Jul 17.


Intrathecal (i.t.) substance P (SP) injection also increases the hypothalamic POMC mRNA level from 1 h to 10 h.
1(0,0,0,1) Details
18639580 Seo YJ, Kwon MS, Choi HW, Choi SM, Nam JS, Lee JK, Jung JS, Park SH, Suh HW: The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models. Pharmacol Biochem Behav. 2008 Nov;91(1):121-7. Epub 2008 Jul 1.


We examined the changes of pain behaviors induced by formalin injected subcutaneously (s.c.) in the hind paw, with substance P (SP) and glutamate injected inthrathecally (i.t.).
1(0,0,0,1) Details