Protein Information

Name NMDA receptors (protein family or complex)
Synonyms Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
19140302 Solntseva SV, Nikitin P: [Neurochemical mechanisms of food aversion conditioning consolidation in snail Helix lucorum]. Ross Fiziol Zh Im I M Sechenova. 2008 Nov;94(11):1259-69.

Effects of cycloheximide, protein synthesis inhibitors, as well as serotonin receptor antagonist and NMDA receptor antagonist on food aversion conditioning consolidation were studied in snail Helix lucorum.
31(0,1,1,1) Details
18825927 Solntseva SV, Nikitin VP: [Neurochemical mechanisms of food aversion conditioning consolidation in snail helix lucorum]. Ross Fiziol Zh Im I M Sechenova. 2008 Aug;94(8):860-70.

Effects of cycloheximide, protein synthesis inhibitor as well as serotonin receptor antagonist and NMDA receptor antagonist, on food aversion conditioning consolidation were studied in snail Helix lucorum.
31(0,1,1,1) Details
19923273 Baumbauer KM, Huie JR, Hughes AJ, Grau JW: Timing in the absence of supraspinal input II: regularly spaced stimulation induces a lasting alteration in spinal function that depends on the NMDA receptor, BDNF release, and protein synthesis. J Neurosci. 2009 Nov 18;29(46):14383-93.

Administration of the protein synthesis inhibitor cycloheximide after training blocked the long-term effect.
3(0,0,0,3) Details
16353388 Wang Z, Ruan Q, Wang D: Different effects of intracochlear sensory and neuronal injury stimulation on expression of synaptic N-methyl-D-aspartate receptors in the auditory cortex of rats in vivo. Acta Otolaryngol. 2005 Nov;125(11):1145-51.

3(0,0,0,3) Details
16606372 Cossenza M, Cadilhe DV, Coutinho RN, Paes-de-Carvalho R: Inhibition of protein synthesis by activation of NMDA receptors in cultured retinal cells: a new mechanism for the regulation of nitric oxide production. J Neurochem. 2006 Jun;97(5):1481-93. Epub 2006 Apr 10.

Although L-[3H] arginine uptake measured in cultured chick retina cells incubated in the presence of cycloheximide (CHX, a protein synthesis inhibitor) was inhibited approximately 75% at equilibrium, quantitative thin-layer chromatography analysis showed that free intracellular L-[3H] arginine was six times higher in CHX-treated than in control cultures.
3(0,0,0,3) Details
16109729 Vickers CA, Dickson KS, Wyllie DJ: Induction and maintenance of late-phase long-term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones. J Physiol. 2005 Nov 1;568(Pt 3):803-13. Epub 2005 Aug 18.

Expression of N-methyl-d-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) in the CA1 region of the hippocampus can be divided into an early (1-2 h), protein synthesis-independent phase and a late (> 4 h), protein synthesis-dependent phase.
Incubation of the slices with the mRNA translation inhibitor cycloheximide or the mammalian target of rapamycin (mTOR) inhibitor rapamycin blocked late-LTP in both 'intact' and 'isolated' slice preparations.
1(0,0,0,1) Details
19490087 Zhang L, Meng K, Li YH, Han TZ: NR2A-containing NMDA receptors are required for L-LTP induction and depotentiation in CA1 region of hippocampal slices. Eur J Neurosci. 2009 Jun;29(11):2137-44. Epub 2009 May 21.

L-LTP partial reversal was also induced by HI-PP-LFS, when the protein synthesis inhibitors anisomycin (25 microm) and cycloheximide (60 microm) were applied following LTP induction.
2(0,0,0,2) Details
18784289 Argilli E, Sibley DR, Malenka RC, England PM, Bonci A: Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area. J Neurosci. 2008 Sep 10;28(37):9092-100.


This cocaine-induced LTP appears to be mediated via dopamine D (5) receptor activation of NMDA receptors and to require protein synthesis.
1(0,0,0,1) Details
15772359 Nosyreva ED, Huber KM: Developmental switch in synaptic mechanisms of hippocampal metabotropic glutamate receptor-dependent long-term depression. J Neurosci. 2005 Mar 16;25(11):2992-3001.


Instead, mGluR-LTD at neonatal synapses results in large decreases in presynaptic function, measured by changes in paired-pulse facilitation and the rate of blockade by the use-dependent NMDA receptor blocker (+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine maleate.
1(0,0,0,1) Details
19247210 Kim J, Park S, Lee S, Choi S: Amygdala depotentiation ex vivo requires mitogen-activated protein kinases and protein synthesis. Neuroreport. 2009 Mar 25;20(5):517-20.


U0126, a mitogen-activated protein kinase inhibitor, and cycloheximide, a protein synthesis inhibitor, blocked depotentiationex vivo.
0(0,0,0,0) Details