| Name | SOCS3 |
|---|---|
| Synonyms | ATOD 4; ATOD4; CIS 3; CIS3; Cish3; Cytokine inducible SH2 protein 3; SOCS 3; SOCS3… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18005266 | Ratthe C, Girard D: Investigation of the interleukin (IL)-4/IL-4 receptor system in promyelocytic leukaemia PLB-985 cells during differentiation toward neutrophil-like phenotype: mechanism involved in IL-4-induced SOCS3 protein expression. Br J Haematol. 2008 Jan;140(1):59-70. Epub 2007 Nov 12. Utilization of catalase, cycloheximide and inhibitors showed that IL-4 induced SOCS3 by a mechanism dependent on a complete oxidase complex, protein synthesis and phosphorylation, but independent of production of reactive species. |
33(0,1,1,3) | Details |
| 17264307 | Ratthe C, Pelletier M, Chiasson S, Girard D: Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling. J Leukoc Biol. 2007 May;81(5):1287-96. Epub 2007 Jan 30. The effect of IL-4 on SOCS3 protein expression was increased markedly when the proteasome inhibitor MG132 was added to the cultures, but this was inhibited by cycloheximide, suggesting that SOCS3 is de novo-synthesized in response to IL-4. |
32(0,1,1,2) | Details |
| 16988072 | Story DJ, Stephens JM: Modulation and lack of cross-talk between signal transducer and activator of transcription 5 and Suppressor of cytokine signaling-3 in insulin and growth hormone signaling in 3T3-L1 adipocytes. Obesity (Silver Spring). 2006 Aug;14(8):1303-11. |
6(0,0,0,6) | Details |
| 16988256 | Dennis VA, Jefferson A, Singh SR, Ganapamo F, Philipp MT: Interleukin-10 anti-inflammatory response to Borrelia burgdorferi, the agent of Lyme disease: a possible role for suppressors of cytokine signaling 1 and 3. Infect Immun. 2006 Oct;74(10):5780-9. We report here that mouse J774 macrophages incubated with IL-10 and added B. burgdorferi spirochetes (freeze-thawed, live, or sonicated) or lipidated outer surface protein A (L-OspA) augmented their SOCS1/SOCS3 mRNA and protein expression, with SOCS3 being more abundant. Neither endogenous IL-10 nor the translation inhibitor cycloheximide blocked SOCS1/SOCS3 induction by B. burgdorferi and its lipoproteins, indicating that the expression of other genes is not required. |
2(0,0,0,2) | Details |
| 15721283 | Choi WH, Ji KA, Jeon SB, Yang MS, Kim H, Min KJ, Shong M, Jou I, Joe EH: Anti-inflammatory roles of in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation. Biochem Biophys Res Commun. 2005 Apr 1;329(1):125-31. Both cRA and tRA induced SOCS3 mRNA expression. Furthermore, the effect of pre-treated RA was abolished in the presence of cycloheximide, indicating a requirement for de novo protein synthesis. |
2(0,0,0,2) | Details |
| 17038666 | Dunlop EA, Maxwell AP, Lappin TR: Impaired downregulation following erythropoietin receptor activation in non-small cell lung carcinoma. Stem Cells. 2007 Feb;25(2):380-4. Epub 2006 Oct 12. Compounding this blunted response is impaired SOCS3 induction downstream of erythropoietin stimulation and an extremely delayed SOCS1 response. |
1(0,0,0,1) | Details |