| Name | p42 |
|---|---|
| Synonyms | CDC2 related kinase 1; p42; CDKL 1; CDKL1; Cyclin dependent kinase like 1; KKIALRE; Protein kinase p42 KKIALRE; Serine/threonine protein kinase KKIALRE… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18184892 | Young SR, Bianchi R, Wong RK: Signaling mechanisms underlying group I mGluR-induced persistent AHP suppression in CA3 hippocampal neurons. J Neurophysiol. 2008 Mar;99(3):1105-18. Epub 2008 Jan 9. Preincubation of slices in inhibitors of protein synthesis (cycloheximide or anisomycin) prevented the persistent suppression of AHPs by |
0(0,0,0,0) | Details |
| 18708082 | Luo SF, Lin CC, Chen HC, Lin WN, Lee IT, Lee CW, Hsiao LD, Yang CM: Involvement of MAPKs, NF-kappaB and p300 co-activator in IL-1beta-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells. Toxicol Appl Pharmacol. 2008 Nov 1;232(3):396-407. Epub 2008 Jul 29. IL-1beta-induced cPLA2 expression and production was inhibited by actinomycin D and cycloheximide, indicating the involvement of transcriptional and translational events in these responses. |
0(0,0,0,0) | Details |
| 16034134 | Grehan JF, Levay-Young BK, Fogelson JL, Francois-Bongarcon V, Benson BA, Dalmasso AP: IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway. J Immunol. 2005 Aug 1;175(3):1903-10. We found that porcine EC incubated with IL-4 or IL-13, but not with IL-10 or IL-11, became protected from killing by complement and apoptosis induced by TNF-alpha plus cycloheximide. |
0(0,0,0,0) | Details |
| 16236272 | Ho AK, McNeil L, Terriff D, Price DM, Chik CL: Role of protein turnover in the activation of p38 mitogen-activated protein kinase in rat pinealocytes. Biochem Pharmacol. 2005 Dec 5;70(12):1840-50. Epub 2005 Oct 19. Differences in the time profiles of activation between p38MAPK and p42/44MAPK by (NE) in rat pinealocytes suggest involvement of mechanisms other than the phosphorylation cascades in their activation. The stimulatory effect of NE on phosphorylated MKK3/6 and p38MAPK, but not phosphorylated p42/44MAPK, was blocked by treatment with actinomycin or cycloheximide, indicating a requirement of transcription and translation in activation of the p38MAPK but not the p42/44MAPK pathway. |
2(0,0,0,2) | Details |
| 15519494 | Yoshida M, Niwa M, Ishisaki A, Hirade K, Ito H, Shimizu K, Kato K, Kozawa O: Methotrexate enhances -stimulated heat shock protein 27 induction in osteoblasts. Prostaglandins Leukot Essent Fatty Acids. 2004 Dec;71(6):351-62. We previously showed that stimulates the induction of heat shock protein 27 (HSP27) via protein kinase C (PKC)-dependent p38 mitogen-activated protein (MAP) kinase and p44/p42 MAP kinase in osteoblast-like MC3T3-E1 cells. |
1(0,0,0,1) | Details |
| 16951370 | Rahman MS, Yamasaki A, Yang J, Shan L, Halayko AJ, Gounni AS: IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK, and p38) pathways. J Immunol. 2006 Sep 15;177(6):4064-71. Taken together, our data provide the first evidence of IL-17A-induced eotaxin-1/CCL11 expression in ASM cells via MAPK (p38, p42/p44 ERK, JNK) signaling pathways. Moreover, IL-17A significantly induced eotaxin-1/CCL11 release and mRNA expression, an effect that was abrogated with cycloheximide and actinomycin D treatment. |
1(0,0,0,1) | Details |
| 16283438 | Yao Y, Kubota T, Sato K, Takeuchi H, Handa Y, Matsukawa S: Cell-specific but p53-independent regulation of vascular endothelial growth factor expression by interferons in human glioblastoma cells. J Neurooncol. 2006 Feb;76(3):219-25. Interestingly, cycloheximide also blocked IFN-induced activation of the p44/p42 mitogen-activated protein kinase, which was partially required for induction of VEGF by IFNs. |
81(1,1,1,1) | Details |
| 15678124 | Meller R, Stevens SL, Minami M, Cameron JA, King S, Rosenzweig H, Doyle K, Lessov NS, Simon RP, Stenzel-Poore MP: Neuroprotection by osteopontin in stroke. . J Cereb Blood Flow Metab. 2005 Feb;25(2):217-25. Osteopontin treatment of cortical neuron cultures caused an increase in Akt and p42/p44 MAPK phosphorylation, which is consistent with OPN-inducing neuroprotection via the activation of these protein kinases. The protective effect of OPN was also blocked by the protein synthesis inhibitor cycloheximide, suggesting that the neuroprotective effect of OPN required new protein synthesis. |
2(0,0,0,2) | Details |
| 18336852 | Lin CC, Tseng HW, Hsieh HL, Lee CW, Wu CY, Cheng CY, Yang CM: Tumor necrosis factor-alpha induces MMP-9 expression via p42/p44 MAPK, JNK, and nuclear factor-kappaB in A549 cells. Toxicol Appl Pharmacol. 2008 Jun 15;229(3):386-98. Epub 2008 Feb 9. Moreover, pretreatment with actinomycin D and cycloheximide attenuated TNF-alpha-induced MMP-9 expression. |
2(0,0,0,2) | Details |
| 15633612 | Yang S, Yip R, Polena S, Sharma M, Rao S, Griciene P, Gintautas J, Jerome H: Reactive species increased focal adhesion kinase production in pulmonary microvascular endothelial cells. Proc West Pharmacol Soc. 2004;47:54-6. Activation of p44 and p42 extracellular signal-regulated protein kinases (ERK1 and ERK2) is an important step in the cascade leading to cell growth and proliferation. We found that low dose H2O2 induced increased FAK production in pulmonary microvascular endothelial cells, which could be blocked by cycloheximide (CHX), a protein synthesis inhibitor. |
1(0,0,0,1) | Details |