Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
18831375 Mathur S, Gupta AK: Histoenzymological study on the toxicity of copper sulphate in the digestive glands of Lymnaea luteola. J Environ Biol. 2008 Mar;29(2):201-4.


On the other hand, same area of the gland showed moderate activity of ATPase during 24 and 48 hr of exposure.
1(0,0,0,1) Details
15836927 Qian Y, Zheng Y, Abraham L, Ramos KS, Tiffany-Castiglioni E: Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells. Brain Res Mol Brain Res. 2005 Apr 4;134(2):323-32. Epub 2005 Jan 13.


Intracellular Cu levels as determined by inductively coupled plasma-mass spectrometry (ICP-MS), and expression levels of copper-transporting ATPase (ATP7A) and human copper transporter 1 (hCtr1) as detected by quantitative reverse transcription-polymerase chain reaction (RT-PCR), were comparable in both cell lines.
1(0,0,0,1) Details
12579329 Harada M, Kumemura H, Sakisaka S, Shishido S, Taniguchi E, Kawaguchi T, Hanada S, Koga H, Kumashiro R, Ueno T, Suganuma T, Furuta K, Namba M, Sugiyama T, Sata M: Wilson disease protein ATP7B is localized in the late endosomes in a polarized human hepatocyte cell line. Int J Mol Med. 2003 Mar;11(3):293-8.

The effects of bathocuproine disulfonate, a copper chelator, and copper sulfate were examined.
1(0,0,0,1) Details
18987288 Craig PM, Galus M, Wood CM, McClelland GB: Dietary iron alters waterborne copper-induced gene expression in soft water acclimated zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R362-73. Epub 2008 Nov 5.


Gene expression levels for divalent metal transport (DMT)-1, copper transporter (CTR)-1, and the basolateral metal transporter ATP7A in the gills and gut increased when compared with controls, but the various combinations of Cu and high-Fe diet revealed altered levels of expression.
1(0,0,0,1) Details
8717422 Lal S, Chithra P, Chandrakasan G: The possible relevance of autoxidative glycosylation in glucose mediated alterations of proteins: an in vitro study on myofibrillar proteins. Mol Cell Biochem. 1996 Jan 26;154(2):95-100.


A significant increase in extent of glycation and decrease in ATPase activity of myofibrils incubated under autoxidative conditions were observed over the other three incubations.
1(0,0,0,1) Details
18707611 Zhang XX, Rainey PB: Regulation of copper homeostasis in Pseudomonas fluorescens SBW25. Environ Microbiol. 2008 Dec;10(12):3284-94. Epub 2008 Aug 14.

When growing on plant surfaces, the plant growth-promoting bacterium Pseudomonas fluorescens SBW25 activates expression of a copper-transporting P1-type ATPase (CueA).
Resistance to exogenously applied copper sulfate shows that cueA and cueR mutants are significantly less resistant than the wild type.
1(0,0,0,1) Details
11959576 Hasman H, Aarestrup FM: tcrB, a gene conferring transferable copper resistance in Enterococcus faecium: occurrence, transferability, and linkage to macrolide and glycopeptide resistance. Antimicrob Agents Chemother. 2002 May;46(5):1410-6.

The tcrB gene encodes a putative protein belonging to the CPx-type ATPase family with homology (46%) to the CopB protein from Enterococcus hirae.
The frequent occurrence of this new copper resistance gene in isolates from pigs, where copper sulfate is being used in large amounts as feed additive, suggests that the use of copper has selected for resistance.
1(0,0,0,1) Details
1288347 Odermatt A, Suter H, Krapf R, Solioz M: An ATPase operon involved in copper resistance by Enterococcus hirae. Ann N Y Acad Sci. 1992 Nov 30;671:484-6.

1(0,0,0,1) Details
8670305 Wojtczak L, Nikitina ER, Czyz A, Skulskii IA: Cuprous ions activate glibenclamide-sensitive potassium channel in liver mitochondria. Biochem Biophys Res Commun. 1996 Jun 14;223(2):468-73.


In K (+)-containing media, Cu+ collapsed the mitochondrial membrane potential formed by operation of the respiratory chain with succinate or tetramethyl p-phenylenediamine + ascorbate as substrates or by the proton-pumping ATPase.
1(0,0,0,1) Details
8048974 Odermatt A, Suter H, Krapf R, Solioz M: Primary structure of two P-type ATPases involved in copper homeostasis in Enterococcus hirae. J Biol Chem. 1993 Jun 15;268(17):12775-9.


CopA exhibits 35% sequence similarity to CopB and 43% similarity to the ATPase encoded by the recently cloned human Mc1 gene, a gene responsible for the Menkes inborn error of copper metabolism.
1(0,0,0,1) Details
17728190 Garcia Sampaio F, de Lima Boijink C, Tie Oba E, Romagueira Bichara dos Santos L, Lucia Kalinin A, Tadeu Rantin F: Antioxidant defenses and biochemical changes in pacu (Piaractus mesopotamicus) in response to single and combined copper and hypoxia exposure. Comp Biochem Physiol C Toxicol Pharmacol. 2008 Jan;147(1):43-51. Epub 2007 Aug 1.


Na (+)/K (+)-ATPase activity in gills decreased in 0.4Cu and 0.4CuHpx, and increased in Hpx.
1(0,0,0,1) Details
10915804 Outten FW, Outten CE, Hale J, O'Halloran TV: Transcriptional activation of an Escherichia coli copper efflux regulon by the chromosomal MerR homologue, cueR. J Biol Chem. 2000 Oct 6;275(40):31024-9.


CopA, the principal copper efflux ATPase in Escherichia coli, is induced by elevated copper in the medium, but the copper-sensing regulatory factor is unknown.
1(0,0,0,1) Details
10593600 Vasic V, Jovanovic D, Krstic D, Nikezic G, Horvat A, Vujisic L, Nedeljkovic N: Prevention and recovery of CuSO4-induced inhibition of Na+/K+ -ATPase and Mg2+ -ATPase in rat brain synaptosomes by EDTA. Toxicol Lett. 1999 Oct 29;110(1-2):95-104.

5(0,0,0,5) Details
17158254 Nyasae L, Bustos R, Braiterman L, Eipper B, Hubbard A: Dynamics of endogenous ATP7A (Menkes protein) in intestinal epithelial cells: copper-dependent redistribution between two intracellular sites. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1181-94. Epub 2006 Dec 7.

5(0,0,0,5) Details
17695505 Matsumoto S, Tanaka T, Kurokawa H, Matsuno K, Hayashida Y, Takahashi T: Effect of copper and role of the copper transporters ATP7A and CTR1 in intracellular accumulation of cisplatin. Anticancer Res. 2007 Jul-Aug;27(4B):2209-16.

4(0,0,0,4) Details
10816044 Fernandes AR, Prieto M, Sa-Correia I: Modification of plasma membrane lipid order and H+-ATPase activity as part of the response of Saccharomyces cerevisiae to cultivation under mild and high copper stress. Arch Microbiol. 2000 Apr;173(4):262-8.

4(0,0,0,4) Details
12782727 Shikanai T, Muller-Moule P, Munekage Y, Niyogi KK, Pilon M: PAA1, a P-type ATPase of Arabidopsis, functions in copper transport in chloroplasts. Plant Cell. 2003 Jun;15(6):1333-46.

2(0,0,0,2) Details
7592871 Sarvazyan NA, Modyanov NN, Askari A: Intersubunit and intrasubunit contact regions of Na+/K (+)-ATPase revealed by controlled proteolysis and chemical cross-linking. J Biol Chem. 1995 Nov 3;270(44):26528-32.

2(0,0,0,2) Details
16773204 Plasencia C, Martinez-Balibrea E, Martinez-Cardus A, Quinn DI, Abad A, Neamati N: Expression analysis of genes involved in oxaliplatin response and development of oxaliplatin-resistant HT29 colon cancer cells. Int J Oncol. 2006 Jul;29(1):225-35.


Our data also confirmed that copper transporters and chaperones are involved in OXA resistance in colorectal cancer cells as evidenced by the overexpression of ATP7A and CCS in response to OXA exposure.
2(0,0,0,2) Details
15681833 Harada M, Kawaguchi T, Kumemura H, Terada K, Ninomiya H, Taniguchi E, Hanada S, Baba S, Maeyama M, Koga H, Ueno T, Furuta K, Suganuma T, Sugiyama T, Sata M: The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein. Am J Pathol. 2005 Feb;166(2):499-510.

2(0,0,0,2) Details
10940034 Riggle PJ, Kumamoto CA: Role of a Candida albicans P1-type ATPase in resistance to copper and silver ion toxicity. J Bacteriol. 2000 Sep;182(17):4899-905.

2(0,0,0,2) Details
19033537 Braiterman L, Nyasae L, Guo Y, Bustos R, Lutsenko S, Hubbard A: Apical targeting and Golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G433-44. Epub 2008 Nov 25.

2(0,0,0,2) Details
20213433 Sampaio FG, de Lima Boijink C, Dos Santos LR, Oba ET, Kalinin AL, Rantin FT: The combined effect of copper and low pH on antioxidant defenses and biochemical parameters in neotropical fish pacu, Piaractus mesopotamicus (Holmberg, 1887). Ecotoxicology. 2010 Mar 6.

Copper sulfate is widely used in aquaculture.
Exposure to 0.4Cu and 0.4CupH resulted in a reduction in the Na (+)/K (+)-ATPase activity and an increase in metallothionein (MT) in the gills.
2(0,0,0,2) Details