| Name | interleukin 10 |
|---|---|
| Synonyms | B TCGF; B cell derived T cell growth factor; CSIF; Cytokine synthesis inhibitory factor; IL 10; IL10; IL10A; Interleukin 10… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17671691 | Kamohara H, Takahashi M, Ishiko T, Ogawa M, Baba H: Induction of interleukin-8 (CXCL-8) by tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells: Impact of CXCL-8 as an autocrine growth factor. Int J Oncol. 2007 Sep;31(3):627-32. Actinomycin D suppressed and cycloheximide augmented CXCL-8 mRNA which was induced by TNF-alpha or not. |
0(0,0,0,0) | Details |
| 16034134 | Grehan JF, Levay-Young BK, Fogelson JL, Francois-Bongarcon V, Benson BA, Dalmasso AP: IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway. J Immunol. 2005 Aug 1;175(3):1903-10. We found that porcine EC incubated with IL-4 or IL-13, but not with IL-10 or IL-11, became protected from killing by complement and apoptosis induced by TNF-alpha plus cycloheximide. |
0(0,0,0,0) | Details |
| 16549420 | Na YJ, Yang SH, Baek DW, Lee DH, Kim KH, Choi YM, Oh ST, Hong YS, Kwak JY, Lee KS: Effects of peritoneal fluid from endometriosis patients on the release of vascular endothelial growth factor by neutrophils and monocytes. Hum Reprod. 2006 Jul;21(7):1846-55. Epub 2006 Mar 20. The VEGF mRNA expression levels in the neutrophils were higher in the EPF, which was abrogated by cycloheximide, suggesting that the EPF induces the production of VEGF in neutrophils. |
0(0,0,0,0) | Details |
| 17948269 | Rossato M, Cencig S, Gasperini S, Cassatella MA, Bazzoni F: IL-10 modulates cytokine gene transcription by protein synthesis-independent and dependent mechanisms in lipopolysaccharide-treated neutrophils. Eur J Immunol. 2007 Nov;37(11):3176-89. Importantly, inhibition of IL-10-induced STAT3 activation and IL-10-suppressive action by a prolonged exposure to cycloheximide (CHX) was observed to occur also in human monocytes and was caused by a defective IL-10-mediated activation of Jak1 and Tyk2 kinases. |
38(0,1,1,8) | Details |
| 19395591 | Kumagai K, Ito K, Ando Y, Hakamata S, Teranishi M, Nakayama H, Manabe S: Neutralization of IL-10 exacerbates cycloheximide-induced hepatocellular apoptosis and necrosis. Toxicol Pathol. 2009;37(4):536-46. Epub 2009 Apr 24. |
12(0,0,1,7) | Details |
| 15769481 | Santiago-Lomeli M, Gomez-Quiroz LE, Ortiz-Ortega VM, Kershenobich D, Gutierrez-Ruiz MC: Differential effect of interleukin-10 on hepatocyte apoptosis. Life Sci. 2005 Apr 15;76(22):2569-79. |
8(0,0,0,8) | Details |
| 16988256 | Dennis VA, Jefferson A, Singh SR, Ganapamo F, Philipp MT: Interleukin-10 anti-inflammatory response to Borrelia burgdorferi, the agent of Lyme disease: a possible role for suppressors of cytokine signaling 1 and 3. Infect Immun. 2006 Oct;74(10):5780-9. Neither endogenous IL-10 nor the translation inhibitor cycloheximide blocked SOCS1/SOCS3 induction by B. burgdorferi and its lipoproteins, indicating that the expression of other genes is not required. |
7(0,0,0,7) | Details |
| 19578789 | Kamimoto M, Mizuno S, Nakamura T: Reciprocal regulation of IL-6 and IL-10 balance by HGF via recruitment of heme oxygenase-1 in macrophages for attenuation of liver injury in a mouse model of endotoxemia. Int J Mol Med. 2009 Aug;24(2):161-70. In the culture of macrophages (Raw264.7), HGF enhanced the LPS-mediated HO-1 induction, and this effect was abolished by cycloheximide, but not by actinomycin-D, thus suggesting that a post-transcriptional pathway is involved in HGF-mediated up-regulation of HO-1. |
6(0,0,0,6) | Details |
| 15847608 | Olivetta E, Pietraforte D, Schiavoni I, Minetti M, Federico M, Sanchez M: HIV-1 Nef regulates the release of anions from human macrophages. Biochem J. 2005 Sep 1;390(Pt 2):591-602. Moreover, we observed that IL-10 (interleukin-10) inhibits release, whereas its depletion restored oxidase activity. |
2(0,0,0,2) | Details |
| 19699525 | Harashima A, Toraya T, Okochi A, Yamamoto M, Suzuki M, Otani T, Inoue T, Tsuji-Takayama K, Sugimoto A, Takeuchi M, Yamasaki F, Nakamura S, Kibata M: Interleukin-8 and RANTES are signature cytokines made by HOZOT, a new type of regulatory T cells. Mol Immunol. 2009 Oct;46(16):3310-9. Epub 2009 Aug 21. Interestingly, IL-8 mRNA was induced by cycloheximide treatment and RANTES showed reduced mRNA but increased protein expression by antibody stimulation. Recently, we established novel cytotoxic regulatory T (Treg) cell lines, HOZOT, which have been characterized as IL-10-producing T cells. |
2(0,0,0,2) | Details |
| 16085794 | Huang HC, Tai FY, Wang FS, Liu CA, Hsu TY, Ou CY, Yang KD: Correlation of augmented IL-8 production to premature chronic lung disease: implication of posttranscriptional regulation. Pediatr Res. 2005 Aug;58(2):216-21. Epub 2005 Jul 29. In the present study, 34 premature infants who required endotracheal intubation within 4 h of birth were recruited for analysis of IL-8, IL-10, and TNF-alpha levels in their bronchoalveolar lavage (BAL) fluid and blood. The augmented IL-8 mRNA expression in cord blood was inhibited by actinomycin D but enhanced by cycloheximide, suggesting that IL-8 production is controlled by de novo transcriptional induction as well as posttranscriptional up-regulation of IL-8 by neonatal leukocytes, relating to the development of CLD. |
1(0,0,0,1) | Details |
| 17286758 | Endoh I, Di Girolamo N, Hampartzoumian T, Cameron B, Geczy CL, Tedla N: Ultraviolet B irradiation selectively increases the production of interleukin-8 in human cord blood-derived mast cells. Clin Exp Immunol. 2007 Apr;148(1):161-7. UVB exposure significantly increased the release of interleukin (IL)-8 and modestly increased IL-1alpha production, but cytokines such as IL-2, IL-4, IL-6, IL-10, IL-12, IL-13, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma were unaffected. Cycloheximide reduced the UVB-mediated induction of IL-8 by 30-40%, suggesting that new protein synthesis contributed to IL-8 production. |
1(0,0,0,1) | Details |
| 15722640 | Park CS, Choi EN, Kim JS, Choi YS, Rhim TY, Chang HS, Chung IY: Interferon-gamma inhibits in vitro mobilization of eosinophils by interleukin-5. Int Arch Allergy Immunol. 2005 Mar;136(3):295-302. Epub 2005 Feb 16. Other cytokines, including IL-1beta, IL-4, IL-10 and IL-13, had little or only slightly enhancing or reducing effects on the shape change. We further analyzed the IFN-gamma effect, showing that pretreatment with IFN-gamma strongly suppressed IL-5-induced eosinophil shape change, and cycloheximide (CHX) abrogated the suppression by IFN-gamma, suggesting that new protein synthesis is required for the inhibitory effect by this cytokine. |
1(0,0,0,1) | Details |
| 19447459 | Mikulak J, Gianolini M, Versmisse P, Pancino G, Lusso P, Verani A: Biological and physical characterization of the X4 HIV-1 suppressive factor secreted by LPS-stimulated human macrophages. Virology. 2009 Jul 20;390(1):37-44. Epub 2009 May 17. MDAF is sensitive to heat and proteinase K treatment, and it appears to be preformed within MDM, in that it is rapidly released upon LPS stimulation and its production is insensitive to cycloheximide, an inhibitor of protein neosynthesis. Finally, MDAF is distinct from several known cytokines that possess anti-HIV-1 activity, including IL-10, IL-12, IL-16, IFN-gamma and alpha-defensins. |
1(0,0,0,1) | Details |
| 17900782 | Kumagai K, Kiyosawa N, Ito K, Yamoto T, Teranishi M, Nakayama H, Manabe S: Influence of Kupffer cell inactivation on cycloheximide-induced hepatic injury. Toxicology. 2007 Nov 30;241(3):106-18. Epub 2007 Aug 25. Thus, Kupffer cell inactivation by the GdCl (3) treatment leads to a loss of the capacity to produce IL-10, supposedly resulting in the enhancement of pro-inflammatory cytokine activities such as tumor necrosis factor (TNF) signaling. |
1(0,0,0,1) | Details |