| Name | NF E2 related factor 2 |
|---|---|
| Synonyms | HEBP 1; HEBP1; NF E2 related factor 2; NFE2 related factor 2; NFE2 related trancription factor 2; NFE2L2; NRF 2; NRF2… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16243960 | Korashy HM, El-Kadi AO: Transcriptional regulation of the NAD (P) H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and Drug Metab Dispos. 2006 Jan;34(1):152-65. Epub 2005 Oct 21. The protein synthesis inhibitor cycloheximide significantly inhibited metal-mediated induction of Nqo1 and Gst ya mRNAs, which coincided with a decrease in the nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression, implying the requirement of Nrf2 protein synthesis for the induction of these genes. |
31(0,1,1,1) | Details |
| 16704410 | Harrison EM, McNally SJ, Devey L, Garden OJ, Ross JA, Wigmore SJ: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells. FEBS J. 2006 Jun;273(11):2345-56. The induction of heme oxygenase-1 in renal adenocarcinoma cells was blocked by actinomycin D and cycloheximide and was abolished by the phosphatidylinositol 3-kinase inhibitor, LY294002, but not by the inactive analog LY303511. The transcription factor NF-E2-related factor-2 was found to translocate to the nucleus following insulin treatment in a phosphatidylinositol 3-kinase-dependent manner. |
3(0,0,0,3) | Details |
| 19653226 | Yeh CT, Chiu HF, Yen GC: Protective effect of on indomethacin-induced cytotoxicity via heme oxygenase-1 expression in human intestinal Int 407 cells. Mol Nutr Food Res. 2009 Sep;53(9):1166-76. is known to be an indirect antioxidant that acts by inducing NF-E2-related factor 2 (Nrf2)-dependent phase II enzymes. Actinomycin D (an RNA synthesis inhibitor) and cycloheximide (a protein synthesis inhibitor) inhibited -responsive HO-1 mRNA expression, indicating that is a requirement for transcription and de novo protein synthesis. |
1(0,0,0,1) | Details |
| 17916901 | Keum YS, Chang PP, Kwon KH, Yuan X, Li W, Hu L, Kong AN: 3-Morpholinopropyl isothiocyanate is a novel synthetic isothiocyanate that strongly induces the antioxidant response element-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo. Carcinogenesis. 2008 Mar;29(3):594-9. Epub 2007 Oct 4. The induction of NF-E2-related factor-2 (Nrf2)-mediated detoxifying/antioxidant enzymes is recognized as an effective strategy for cancer chemoprevention. Using chemical inhibitors of protein synthesis (cycloheximide) and 26S proteosomal degradation (MG-132), we observed that the induction of Nrf2 protein by 3MP-ITC appeared to be post-translationally regulated. 3MP-ITC activated ERK1/2 and JNK1/2 and the activation of antioxidant response element (ARE) by 3MP-ITC was significantly attenuated by chemical inhibition of PKC and PI3K signaling pathways in HepG2C8 cells. |
1(0,0,0,1) | Details |
| 17189831 | Warabi E, Takabe W, Minami T, Inoue K, Itoh K, Yamamoto M, Ishii T, Kodama T, Noguchi N: Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive / species. Free Radic Biol Med. 2007 Jan 15;42(2):260-9. Epub 2006 Oct 20. Nrf2 was rapidly degraded in cells treated with cycloheximide under static conditions, but shear stress decreased the rate of Nrf2 degradation. |
2(0,0,0,2) | Details |
| 18440740 | Song HJ, Shin CY, Oh TY, Sohn UD: The protective effect of eupatilin on indomethacin-induced cell damage in cultured feline ileal smooth muscle cells: involvement of HO-1 and ERK. J Ethnopharmacol. 2008 Jun 19;118(1):94-101. Epub 2008 Mar 22. We also found that PD98059, a MEK (MAPK/ERK kinase) inhibitor, attenuated the eupatilin-induced HO-1 expression and nuclear translocation of transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2). Pretreatment of ISMC with cycloheximide, an inhibitor of protein synthesis, attenuated the cytoprotective effect of eupatilin, suggesting that eupatilin induces proteins that are responsible for the cytoprotection. |
1(0,0,0,1) | Details |
| 15870071 | Vargas MR, Pehar M, Cassina P, Martinez-Palma L, Thompson JA, Beckman JS, Barbeito L: Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. J Biol Chem. 2005 Jul 8;280(27):25571-9. Epub 2005 May 3. FGF-1 induced the expression of HO-1 in cultured rat spinal cord astrocytes, which was dependent on FGF receptor activation and prevented by cycloheximide. |
1(0,0,0,1) | Details |
| 19897490 | Kaspar JW, Jaiswal AK: Antioxidant-induced phosphorylation of 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression. J Biol Chem. 2010 Jan 1;285(1):153-62. Epub 2009 Nov 6. Bach1 levels inside the nucleus returned to normal at 4 h after antioxidant treatment in the absence but not in the presence of protein synthesis inhibitor cycloheximide. Antioxidants cause stabilization and nuclear translocation of NF-E2-related factor 2 (Nrf2), where it binds to the antioxidant response element (ARE) and induces up-regulation of defensive genes that protect cells against oxidative and electrophilic stress. |
1(0,0,0,1) | Details |
| 17652445 | Purdom-Dickinson SE, Sheveleva EV, Sun H, Chen QM: Translational control of nrf2 protein in activation of antioxidant response by oxidants. Mol Pharmacol. 2007 Oct;72(4):1074-81. Epub 2007 Jul 25. Nf-E2 related factor-2 (Nrf2) is a basic zipper transcription factor that binds and activates the antioxidant response element (ARE) in the promoters of many antioxidant and detoxification genes. Although inhibiting protein synthesis with cycloheximide prevented H (2) O (2) from elevating Nrf2 protein level, RNA synthesis inhibition with actinomycin D failed to do so. |
1(0,0,0,1) | Details |