Protein Information

Name IL 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
17535659 Jian XD, Sui H, Chu ZH, Zhang ZW, Kan BT, Zhang L, Zhang HT: [Changes of serum cytokine caused by acute paraquat poisoning] . Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007 Apr;25(4):230-2.

OBJECTIVE: To observe the change of cytokine interleukin IL-1 beta, IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha) occurred in acute paraquat (PQ) poisoning rats and to investigate the mechanism of acute lung injury caused by paraquat (PQ) poisoning.
32(0,1,1,2) Details
11527818 Sun D, Muthukumar AR, Lawrence RA, Fernandes G: Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL/6 mice. Clin Diagn Lab Immunol. 2001 Sep;8(5):1003-11.

We report here on the influence of CR on the response of peritoneal macrophages to lipopolysaccharide, splenic NF-kappaB and NF-interleukin-6 (IL-6) activities, and mortality in polymicrobial sepsis induced by cecal ligation and puncture (CLP).
However, mice under CR survived significantly (P < 0.005) longer than mice fed ad libitum when injected with paraquat, a free radical-inducing agent.
2(0,0,0,2) Details
19505674 Santana MC, Garcia CS, Xisto DG, Nagato LK, Lassance RM, Prota LF, Ornellas FM, Capelozzi VL, Morales MM, Zin WA, Pelosi P, Rocco PR: Prone position prevents regional alveolar hyperinflation and mechanical stress and strain in mild experimental acute lung injury. Respir Physiol Neurobiol. 2009 Jun 30;167(2):181-8. Epub 2009 Apr 14.

In experimental mild acute lung injury (ALI), arterial oxygen partial pressure (Pa O2), lung mechanics and histology, inflammatory markers [interleukin (IL)-6 and IL-1 beta], and type III procollagen (PCIII) mRNA expressions were analysed in supine and prone position.
In controls, saline was intraperitoneally injected while ALI was induced by paraquat.
1(0,0,0,1) Details
16761421 Liu R, Wang CH, Huang MH, Li X, Qiang O, Tang CW: [Therapeutic effect of somatostatin on acute respiratory distress syndrome in experimental rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 May;37(3):412-5.

METHODS: ARDS rat model was induced by administration of paraquat.
In addition, TNF-alpha and IL-6 levels in plasma, Bronchoalveolar lavage fluids (BALF) and intestine homogenate were measured respectively.
1(0,0,0,1) Details
20333356 Saddy F, Oliveira GP, Garcia CS, Nardelli LM, Rzezinski AF, Ornellas DS, Morales MM, Capelozzi VL, Pelosi P, Rocco PR: Assisted ventilation modes reduce the expression of lung inflammatory and fibrogenic mediators in a model of mild acute lung injury. Intensive Care Med. 2010 Mar 24.

Bivent + PSV led to less alveolar epithelium injury and lower expression of tumour necrosis factor-alpha, interleukin-6, and type III procollagen.
METHODS: Paraquat-induced ALI rats were studied.
1(0,0,0,1) Details
18187236 Mangano EN, Hayley S: Inflammatory priming of the substantia nigra influences the impact of later paraquat exposure: Neuroimmune sensitization of neurodegeneration. Neurobiol Aging. 2009 Sep;30(9):1361-78. Epub 2008 Jan 10.

Circulating levels of the inflammatory cytokines, interleukin (IL)-6, IL-2, tumor necrosis factor-alpha and interferon-gamma were also time-dependently elevated following intra-SNc LPS infusion.
1(0,0,0,1) Details
17215068 Tomita M, Okuyama T, Katsuyama H, Miura Y, Nishimura Y, Hidaka K, Otsuki T, Ishikawa T: Mouse model of paraquat-poisoned lungs and its gene expression profile. Toxicology. 2007 Mar 7;231(2-3):200-9. Epub 2006 Dec 15.

These genes are Mt1, Mt2, Hmox1, Gcl, GR, IL-6, IL-13, Txn1, Fas, FasL, Lpin2, Mmp1a, Mmp12, Sfp-B, Sfp-D, CAT, EC-SOD, GST, and Pltp.
1(0,0,0,1) Details