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Sorenson JR, Wangila GW: Co-treatment with copper compounds dramatically decreases toxicities observed with cisplatin cancer therapy and the anticancer efficacy of some copper chelates supports the conclusion that copper chelate therapy may be markedly more effective and less toxic than cisplatin therapy. Curr Med Chem. 2007;14(14):1499-503.
Initially it was found that copper sulfate treatment completely prevented lethality as well as gastric and nephrotoxicity without compromising Pt (II) (NH3) 2 (CL) 2 antineoplastic activity, which led to suggestions that prior Cu (II)-treatment be used clinically to prevent serious side effects of Pt (II) (NH3) 2 (CL) 2-treatment. |
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