Protein Information

Name cathepsin B
Synonyms APP secretase; APPS; Amyloid precursor protein secretase; CPSB; CTSB; Cathepsin B; Cathepsin B precursor; Cathepsin B1…

Compound Information

Name phosphine
CAS phosphine

Reference List

PubMed Abstract RScore(About this table)
18164406 Gunatilleke SS, Barrios AM: Tuning the Au (I)-mediated inhibition of cathepsin B through ligand substitutions. J Inorg Biochem. 2008 Mar;102(3):555-63. Epub 2007 Nov 22.

In this study, the extent to which the steric and electronic properties of the phosphine ligand can be modified to obtain enhanced potency against cathepsin B is investigated.
83(1,1,1,3) Details
18253767 Gunatilleke SS, de Oliveira CA, McCammon JA, Barrios AM: Inhibition of cathepsin B by Au (I) complexes: a kinetic and computational study. J Biol Inorg Chem. 2008 May;13(4):555-61.

Here we employ a combination of experimental and computational investigations into the effect of changes in the phosphine ligand of auranofin on its in vitro inhibition of cathepsin B.
82(1,1,1,2) Details