| 19780128 |
Zhang LY, Xu XL, Luo ZF, Wu H, Shen DK, Peng LL, Liu YZ: Small-molecule reductants inhibit multicatalytic activity of AA-NADase from Agkistrodon acutus venom by reducing the disulfide-bonds and Cu (II) of enzyme. Biopolymers. 2010 Feb;93(2):141-9.
L-ascorbate inhibits AA-NADase on both NADase and ADPase activities through the reduction of Cu (II) in AA-NADase to Cu (I), while other reductants, dithiothreitol, glutathione and tris (2-carboxyethyl) phosphine inhibit both NADase and ADPase activities through the reduction of Cu (II) to Cu (I) and the cleavage of disulfide-bonds in AA-NADase. |
84(1,1,1,4) |
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