| Name | XRN1 |
|---|---|
| Synonyms | 5' 3' exoribonuclease 1; SEP 1; SEP1; 5' 3' exoribonuclease 1; DNA Strand exchange protein SEP1; Exoribonuclease 1; Strand exchange protein 1; Strand exchange protein 1 homolog… |
| Name | benomyl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9315672 | Johnson AW: Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and cytoplasm, respectively. Mol Cell Biol. 1997 Oct;17(10):6122-30. These RAT1 alleles restored XRN1-like functions, including cytoplasmic RNA turnover, wild-type sensitivity to the microtubule-destabilizing drug benomyl, and sporulation. |
82(1,1,1,2) | Details |
| 8529461 | Bashkirov VI, Solinger JA, Heyer WD: Identification of functional domains in the Sep1 protein (= Kem1, Xrn1), which is required for transition through meiotic prophase in Saccharomyces cerevisiae. Chromosoma. 1995 Nov;104(3):215-22. The most striking phenotype of SEP1 null mutations is quantitative arrest during meiotic prophase at the pachytene stage. Analysis of these deletion mutations on plasmids in a host carrying a null allele (sep1 ) revealed that at least 270 amino acids from the C-terminus of the wild-type protein were dispensable for complementing the slow growth and benomyl hypersensitivity of a null mutant. |
2(0,0,0,2) | Details |
| 7720696 | Interthal H, Bellocq C, Bahler J, Bashkirov VI, Edelstein S, Heyer WD: A role of Sep1 (= Kem1, Xrn1) as a microtubule-associated protein in Saccharomyces cerevisiae. EMBO J. 1995 Mar 15;14(6):1057-66. Saccharomyces cerevisiae cells lacking the SEP1 (also known as XRN1, KEM1, DST2, RAR5) gene function exhibit a number of phenotypes in cellular processes related to microtubule function. Mutant cells show increased sensitivity to the microtubule-destabilizing drug benomyl, increased chromosome loss, a karyogamy defect, impaired spindle pole body separation, and defective nuclear migration towards the bud neck. |
2(0,0,0,2) | Details |