| Name | MDR1 |
|---|---|
| Synonyms | ABC20; MDR1; ABCB 1; ABCB1; ATP binding cassette sub family B member 1; CD243; CD243 antigen; CLCS… |
| Name | benomyl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17159223 | Rognon B, Kozovska Z, Coste AT, Pardini G, Sanglard D: Identification of promoter elements responsible for the regulation of MDR1 from Candida albicans, a major facilitator transporter involved in azole resistance. Microbiology. 2006 Dec;152(Pt 12):3701-22. It is required for benomyl-dependent MDR1 upregulation and is also necessary for constitutive high expression of MDR1. |
14(0,0,1,9) | Details |
| 18809934 | Schubert S, Rogers PD, Morschhauser J: Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. Antimicrob Agents Chemother. 2008 Dec;52(12):4274-80. Epub 2008 Sep 22. When C. dubliniensis MRR1 (CdMRR1) was expressed in C. albicans mrr1Delta mutants, it restored benomyl-inducible MDR1 expression, demonstrating that CdMRR1 is the ortholog of CaMRR1. |
12(0,0,1,7) | Details |
| 16801405 | Hiller D, Stahl S, Morschhauser J: Multiple cis-acting sequences mediate upregulation of the MDR1 efflux pump in a fluconazole-resistant clinical Candida albicans isolate. Antimicrob Agents Chemother. 2006 Jul;50(7):2300-8. In contrast, deletion of one of these regions abolished benomyl-induced MDR1 expression in a C. albicans laboratory strain. |
12(0,0,1,7) | Details |
| 15980350 | Harry JB, Oliver BG, Song JL, Silver PM, Little JT, Choiniere J, White TC: Drug-induced regulation of the MDR1 promoter in Candida albicans. Antimicrob Agents Chemother. 2005 Jul;49(7):2785-92. MDR1 mRNA levels in a susceptible clinical isolate are induced by benomyl (BEN) but not by other drugs previously shown to induce MDR1. |
8(0,0,0,8) | Details |
| 11709317 | Wirsching S, Moran GP, Sullivan DJ, Coleman DC, Morschhauser J: MDR1-mediated drug resistance in Candida dubliniensis. Antimicrob Agents Chemother. 2001 Dec;45(12):3416-21. In contrast, CdMDR1 inactivation did not cause increased susceptibility to amorolfine, terbinafine, fluphenazine, and benomyl, although overexpression of CdMDR1 in a hypersusceptible Saccharomyces cerevisiae strain had previously been shown to confer resistance to these compounds. |
1(0,0,0,1) | Details |
| 11292806 | Staib P, Moran GP, Sullivan DJ, Coleman DC, Morschhauser J: Isogenic strain construction and gene targeting in Candida dubliniensis. J Bacteriol. 2001 May;183(9):2859-65. Fluconazole had no effect on MDR1 expression, but the addition of the drug benomyl strongly activated the reporter gene fusion in a dose-dependent fashion, demonstrating that the CdMDR1 gene, which encodes an efflux pump mediating resistance to toxic compounds, is induced by the presence of certain drugs. The URA3 gene from C. albicans (CaURA3) was then used as a selection marker for targeted integration of a fusion between the C. dubliniensis MDR1 (CdMDR1) promoter and a C. albicans-adapted GFP reporter gene. |
1(0,0,0,1) | Details |
| 2062311 | Fling ME, Kopf J, Tamarkin A, Gorman JA, Smith HA, Koltin Y: Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate. Mol Gen Genet. 1991 Jun;227(2):318-29. |
0(0,0,0,0) | Details |