Protein Information

Name microtubule associated protein
Synonyms GOLSYN; Golgi localized syntaphilin related protein; Golgi localized syntaphilin related proten A; Golgi localized syntaphilin related proten B; Golgi localized syntaphilin related proten C; Microtubule associated protein; SYBU; Syntabulin…

Compound Information

Name benomyl
CAS

Reference List

PubMed Abstract RScore(About this table)
12206654 Steinberg-Neifach O, Eshel D: Heterozygosity in MAT locus affects stability and function of microtubules in yeast. Biol Cell. 2002 Jun;94(3):147-56.


The dynamic nature of microtubules is important for their cellular function and is tightly regulated by the cell cycle machinery and through other pathways that act on microtubule-associated proteins.
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16567500 Al-Bassam J, van Breugel M, Harrison SC, Hyman A: Stu2p binds tubulin and undergoes an open-to-closed conformational change. J Cell Biol. 2006 Mar 27;172(7):1009-22.


Stu2p from budding yeast belongs to the conserved Dis1/XMAP215 family of microtubule-associated proteins (MAPs).
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12454057 Brew CT, Huffaker TC: The yeast ubiquitin protease, Ubp3p, promotes protein stability. Genetics. 2002 Nov;162(3):1079-89.


Stu1p is a microtubule-associated protein required for spindle assembly.
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7720696 Interthal H, Bellocq C, Bahler J, Bashkirov VI, Edelstein S, Heyer WD: A role of Sep1 (= Kem1, Xrn1) as a microtubule-associated protein in Saccharomyces cerevisiae. EMBO J. 1995 Mar 15;14(6):1057-66.

Mutant cells show increased sensitivity to the microtubule-destabilizing drug benomyl, increased chromosome loss, a karyogamy defect, impaired spindle pole body separation, and defective nuclear migration towards the bud neck.
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18710370 Ferrand A, Chevrier V, Chauvin JP, Birnbaum D: Ajuba: a new microtubule-associated protein that interacts with BUBR1 and Aurora B at kinetochores in metaphase. Biol Cell. 2009 Apr;101(4):221-35.

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1398097 Russo P, Juuti JT, Raudaskoski M: Cloning, sequence and expression of a beta-tubulin-encoding gene in the homobasidiomycete Schizophyllum commune. Gene. 1992 Oct 1;119(2):175-82.

The S. commune beta Tub shows a conserved aa sequence in the C-terminal domain, which is suggested to interact with microtubule-associated proteins in animals.
In contrast, the S. commune beta Tub deviates from most known beta Tubs by having a Cys165 residue, which might be significant for the insensitivity of S. commune haploid strains to the antimicrotubule drug, benomyl.
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