Protein Information

Name vitronectin
Synonyms Complement S protein; S protein; Serum spreading factor; Somatomedin B; V75; VN; VNT; VTN…

Compound Information

Name sodium chlorate
CAS sodium chlorate

Reference List

PubMed Abstract RScore(About this table)
9164657 Wilkins-Port CE, McKeown-Longo PJ: Heparan sulfate proteoglycans function in the binding and degradation of vitronectin by fibroblast monolayers. Biochem Cell Biol. 1996;74(6):887-97.

Sodium chlorate, a competitive inhibitor of proteoglycan sulfation, produced a dose-dependent decrease in both binding and degradation of vitronectin.
171(2,2,2,11) Details
12694655 Kokenyesi R, Murray KP, Benshushan A, Huntley ED, Kao MS: Invasion of interstitial matrix by a novel cell line from primary peritoneal carcinosarcoma, and by established ovarian carcinoma cell lines: role of cell-matrix adhesion molecules, proteinases, and E-cadherin expression. Gynecol Oncol. 2003 Apr;89(1):60-72.

RESULTS: PC880 cells adhered well to fibronectin, laminin, and vitronectin in an integrin-dependent manner.
Treatment of PC880 cells with sodium chlorate also decreased invasiveness (80% of control), further confirming the role of cell surface proteoglycans.
1(0,0,0,1) Details