| Name | FGFR1 |
|---|---|
| Synonyms | BFGFR; Tyrosylprotein kinase; Protein tyrosine kinase; H5; H4; Hydroxyaryl protein kinase; Basic fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1 precursor… |
| Name | sodium chlorate |
|---|---|
| CAS | sodium chlorate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15767480 | Siffroi-Fernandez S, Cinaroglu A, Fuhrmann-Panfalone V, Normand G, Bugra K, Sahel J, Hicks D: Acidic fibroblast growth factor (FGF-1) and FGF receptor 1 signaling in human Y79 retinoblastoma. Arch Ophthalmol. 2005 Mar;123(3):368-76. We sought to examine FGF high- and low-affinity receptor (FGFR) expression, activation of FGFR1 by acidic FGF (FGF-1), and proliferative effects on Y79 cells. Low-affinity heparan sulfate proteoglycan coreceptors were blocked through sodium chlorate or heparinase treatment of Y79 cells. |
8(0,0,0,8) | Details |
| 14517424 | Natke B, Venkataraman G, Nugent MA, Sasisekharan R: Heparinase treatment of bovine smooth muscle cells inhibits fibroblast growth factor-2 binding to fibroblast growth factor receptor but not FGF-2 mediated cellular proliferation. Angiogenesis. 1999;3(3):249-57. On the surface of smooth muscle cells there are two types of receptors for the mitogenic and angiogenic growth factor fibroblast growth factor-2 (FGF-2); a high affinity tyrosine kinase FGF receptor (FGFR1) and low affinity /heparan-like glycosaminoglycan (HLGAG) component of surface expressed proteoglycans. Through the use of both sodium chlorate and FGF-2 mutants with deficient HLGAG-binding capabilities, we show the FGF-2-HLGAG interaction is important for FGF-2's ability to induce SMC proliferation. |
2(0,0,0,2) | Details |
| 12423248 | Deguchi Y, Okutsu H, Okura T, Yamada S, Kimura R, Yuge T, Furukawa A, Morimoto K, Tachikawa M, Ohtsuki S, Hosoya K, Terasaki T: Internalization of basic fibroblast growth factor at the mouse blood-brain barrier involves perlecan, a heparan sulfate proteoglycan. J Neurochem. 2002 Oct;83(2):381-9. Moreover, the -resistant binding of [125I] bFGF in TM-BBB4 cells was significantly reduced by 50% following treatment with sodium chlorate, suggesting the loss of perlecan (a core protein of heparan sulfate proteoglycan, HSPG) from the extracellular matrix of the cells. RT-PCR analysis revealed that HSPG mRNA and FGFR1 and FGFR2 (tyrosine-kinase receptors for bFGF) mRNA are expressed in TM-BBB4 cells. |
1(0,0,0,1) | Details |
| 7672514 | Chen JK, Chao HH, Yang VC: Inhibition of the growth of a human nasopharyngeal carcinoma cell line by bFGF is mediated via FGFR-1. FASEB J. 1995 Sep;9(12):1211-9. The biological effect of bFGF is conveyed through its binding to the high-affinity receptor sites and the binding is dependent on the presence of cell surface -like molecules, as treatment of cells with heparitinase or sodium chlorate abolishes high-affinity binding and growth inhibition. |
1(0,0,0,1) | Details |
| 10366041 | Zhu X, Sasse J, Lough J: Evidence that FGF receptor signaling is necessary for endoderm-regulated development of precardiac mesoderm. Mech Ageing Dev. 1999 Apr 1;108(1):77-85. Using sodium chlorate, which prevents FGF ligand-receptor interaction, it was observed that the percentage of S-phase precardiac mesoderm cells was markedly reduced, suggesting that cell proliferation was inhibited. To more specifically affect FGF signaling, the explants were treated with an antibody that recognizes an extracellular domain of FGF receptor-1 (FGFR-1). |
1(0,0,0,1) | Details |