Protein Information

Name MT 4
Synonyms MT 4; MT IV; MT4; MTIV; Metallothionein 4; Metallothionein IV; Metallothionein 4s; Metallothionein IVs

Compound Information

Name sodium chlorate
CAS sodium chlorate

Reference List

PubMed Abstract RScore(About this table)
8985938 Ohshiro Y, Murakami T, Matsuda K, Nishioka K, Yoshida K, Yamamoto N: Role of cell surface glycosaminoglycans of human T cells in human immunodeficiency virus type-1 (HIV-1) infection. Microbiol Immunol. 1996;40(11):827-35.

Heparitinase I (hep I) and sodium chlorate prevented binding of HIV-1/IIIB to MT-4 cells as revealed by indirect immunofluorescence procedures, thereby inhibiting infection.
82(1,1,1,2) Details
8096145 Patel M, Yanagishita M, Roderiquez G, Bou-Habib DC, Oravecz T, Hascall VC, Norcross MA: Cell-surface heparan sulfate proteoglycan mediates HIV-1 infection of T-cell lines. AIDS Res Hum Retroviruses. 1993 Feb;9(2):167-74.

HIV-1-susceptible lymphoblastic T-cell lines, MT-4 and H9, were analyzed for proteoglycan synthesis and found to make heparan sulfate (HS) and chondroitin sulfate proteoglycans.
Sulfation of glycosaminoglycans HS chains was critical to viral entry as shown by inhibition of viral infection with sodium chlorate and its specific reversal with exogenous sulfate addition.
1(0,0,0,1) Details