| Name | aFGF |
|---|---|
| Synonyms | AFGF; Acidic fibroblast growth factor; Beta endothelial cell growth factor; ECGF; ECGF beta; ECGFA; ECGFB; ECGFbeta… |
| Name | sodium chlorate |
|---|---|
| CAS | sodium chlorate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14966081 | Newman DR, Li CM, Simmons R, Khosla J, Sannes PL: affects signaling pathways stimulated by fibroblast growth factor-1 and -2 in type II cells. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L191-200. Epub 2004 Feb 13. In addition, experiments were done on cells grown in the presence of 20 mM sodium chlorate (sulfation inhibitor). |
1(0,0,0,1) | Details |
| 7672514 | Chen JK, Chao HH, Yang VC: Inhibition of the growth of a human nasopharyngeal carcinoma cell line by bFGF is mediated via FGFR-1. FASEB J. 1995 Sep;9(12):1211-9. In contrast, aFGF, which has a 55% homology in amino acid sequence with bFGF, stimulates cell growth. The biological effect of bFGF is conveyed through its binding to the high-affinity receptor sites and the binding is dependent on the presence of cell surface -like molecules, as treatment of cells with heparitinase or sodium chlorate abolishes high-affinity binding and growth inhibition. |
2(0,0,0,2) | Details |
| 7528211 | Reich-Slotky R, Bonneh-Barkay D, Shaoul E, Bluma B, Svahn CM, Ron D: Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and acidic fibroblast growth factor to the KGF receptor. J Biol Chem. 1994 Dec 23;269(51):32279-85. Treatment of cells with sodium chlorate, which blocks sulfation of proteoglycans, reduced the binding of aFGF to its low and high affinity binding sites by 95 and 80%, respectively. |
87(1,1,1,7) | Details |