Protein Information

Name E12
Synonyms E12; ELSPBP 1; ELSPBP1; Epididymal sperm binding protein 1; HE12; Seminal plasma protein like protein; Epididymal sperm binding protein 1s; Seminal plasma protein like proteins

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
7472497 Sernagor E, Chub N, Ritter A, O'Donovan MJ: Pharmacological characterization of the rhythmic synaptic drive onto lumbosacral motoneurons in the chick embryo spinal cord. J Neurosci. 1995 Nov;15(11):7452-64.

The pause in sartorius firing was shortened following local application of the glycine antagonist strychnine the nicotinic, cholinergic antagonists mecamylamine, and dihydro-beta-erythroidine and several excitatory amino acid antagonists.
To address these questions we have investigated the pharmacology of the rhythmic, synaptic drive to lumbosacral motoneurons using local and bath application of several excitatory and inhibitory antagonists, and documenting their effects on motor output in E10-E12 chick embryos.
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8492110 Kitchener PD, Laing NG: Brachially innervated ectopic hindlimbs in the chick embryo. J Neurobiol. 1993 Mar;24(3):335-43.

After E12, the grafted hindlimbs of chronic spinal embryos displayed significantly fewer movements than the normal forelimbs of chronic spinal embryos but significantly more movements than the brachial hindlimb of embryos with intact spinal cords.
However, the virtually immobile grafted hindlimbs of E20 embryos exhibited strong, synchronous contractions of gastrocnemius and tibialis muscles upon intraperitoneal injection of strychnine nitrate (20 micrograms).
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