| Name | cis 4 |
|---|---|
| Synonyms | CIS 4; SOCS 4; SOCS4; Suppressor of cytokine signaling 4; CIS4; Cish4; Cytokine inducible SH2 protein 4; HSPC060… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8386310 | Woodward RM, Polenzani L, Miledi R: Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in Xenopus oocytes. Mol Pharmacol. 1993 Apr;43(4):609-25. Conformationally restricted analogues trans- and cis-4-aminocrotonic acid (TACA and CACA) were agonists at the rho-like receptors. Strychnine (Kb congruent to 70) and SR-95531 (Kb congruent to 35) also were competitive inhibitors of the rho-like receptors but were, respectively, 20 and 240 times more potent at GABAA receptors. |
1(0,0,0,1) | Details |
| 10561820 | Chebib M, Johnston GA: The 'ABC' of GABA receptors: a brief review. Clin Exp Pharmacol Physiol. 1999 Nov;26(11):937-40. Instead, GABAC receptors are selectively activated by the conformationally restricted analogues of in the folded conformation cis-4-aminocrotonic acid and (1s,2R)-2-(aminomethyl)-1-carboxycyclopropane. (1,2,5,6-Tetrahydropyridine-4-yl) methylphosphinic acid, a methylphosphinic acid analogue of in a partially folded conformation, is a selective antagonist at GABAC receptors. GABAA and GABAC receptors are members of a super-family of transmitter-gated ion channels that include nicotinic acetylcholine, strychnine-sensitive and 5HT3 receptors. |
1(0,0,0,1) | Details |
| 7623156 | Zhou ZJ, Fain GL: Neurotransmitter receptors of starburst amacrine cells in rabbit retinal slices. J Neurosci. 1995 Jul;15(7 Pt 2):5334-45. (30-200 microM) also activated a Cl- conductance in starburst cells, which could be completely blocked by strychnine. |
0(0,0,0,0) | Details |
| 8890310 | Hare WA, Owen WG: Receptive field of the retinal bipolar cell: a pharmacological study in the tiger salamander. J Neurophysiol. 1996 Sep;76(3):2005-19. Surround responses were not blocked by or its antagonist strychnine, or by combinations of drugs designed to eliminate GABAergic and glycinergic pathways simultaneously. 7. |
0(0,0,0,0) | Details |