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Speranskiy K, Cascio M, Kurnikova M: Homology modeling and molecular dynamics simulations of the glycine receptor ligand binding domain. Proteins. 2007 Jun 1;67(4):950-60.
Using two template proteins with known structure to model three dimensional structure of a target protein is especially advantageous for sequences with low homology as in the case presented in this paper.
In addition, a complex structure with strychnine antagonist in the putative binding site is proposed based on docking simulation using Autodock program. |
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