Protein Information

Name AIDA
Synonyms AIDA; EB1; AIDA 1; AIDA 1a; AIDA 1b; AIDA 1bDAnk; AIDA 1bDelta Ank 2; AIDA1…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
14984404 Taccola G, Marchetti C, Nistri A: Modulation of rhythmic patterns and cumulative depolarization by group I metabotropic glutamate receptors in the neonatal rat spinal cord in vitro. Eur J Neurosci. 2004 Feb;19(3):533-41.

Disinhibited bursting induced by strychnine + bicuculline was accelerated by DHPG, slowed down by AIDA (which prevented the action of DHPG), unaffected by MPEP and counteracted by the selective group II agonist (2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl) glycine.
34(0,1,1,4) Details
14622220 Marchetti C, Taccola G, Nistri A: Distinct subtypes of group I metabotropic glutamate receptors on rat spinal neurons mediate complex facilitatory and inhibitory effects. Eur J Neurosci. 2003 Oct;18(7):1873-83.


The group I agonist DHPG evoked motoneuron depolarization (via the AIDA or CPCCOEt-sensitive mGlu receptor subtype 1) mainly at network level and generated sustained, network-dependent oscillations (via the MPEP-sensitive mGlu receptor subtype 5).
2(0,0,0,2) Details
16836978 Jung SJ, Kim SJ, Park YK, Oh SB, Cho K, Kim J: Group I mGluR regulates the polarity of spike-timing dependent plasticity in substantia gelatinosa neurons. Biochem Biophys Res Commun. 2006 Aug 25;347(2):509-16. Epub 2006 Jun 30.

In the presence of bicuculline and strychnine, long-term potentiation (LTP) was blocked by AP-5 and Ca2+ chelator BAPTA-AM.
The group I mGluR antagonist AIDA, PLC inhibitor U-73122, and IP3 receptor blocker 2-APB shifted LTP to long-term depression (LTD) without affecting acute synaptic transmission.
1(0,0,0,1) Details