| Name | sodium channel (protein family or complex) |
|---|---|
| Synonyms | Sodium channel |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19348729 | Han SK, Park SA, Jeon JG, Chang KW, Ahn DK, Oh SB, Park SJ: Functional type I vanilloid receptor expression by substantia gelatinosa neurons of trigeminal subnucleus caudalis in mice. Neurosci Lett. 2009 Mar 20;452(3):228-31. Epub 2009 Jan 29. -induced depolarization was maintained in 20 out of 32 (63%) SG neurons in the presence of amino acid and voltage-dependent sodium channel blockers (10 microM CNQX, 20 microM AP-5, 0.5 microM TTX, 50 microM picrotoxin and 2 microM strychnine). |
6(0,0,1,1) | Details |
| 19111909 | Chindo BA, Anuka JA, McNeil L, Yaro AH, Adamu SS, Amos S, Connelly WK, Lees G, Gamaniel KS: Anticonvulsant properties of saponins from Ficus platyphylla stem bark. Brain Res Bull. 2009 Mar 30;78(6):276-82. Epub 2008 Dec 26. SFG impaired membrane excitability; a property shared by most anticonvulsants particularly the voltage-gated sodium channel (VGSC) blocking drugs, thus supporting the isolation and development of the saponin components of this plant as anticonvulsant agents. The anticonvulsant properties of the saponin rich fraction (SFG) obtained from the extract of F. platyphylla stem bark were studied on pentylenetetrazole-, strychnine- and maximal electroshock seizures in mice. |
1(0,0,0,1) | Details |
| 17173871 | Molchanova SM, Oja SS, Saransaari P: Inhibitory effect of on veratridine-evoked D-[3H] release from murine corticostriatal slices: involvement of channels and mitochondria. Brain Res. 2007 Jan 26;1130(1):95-102. Epub 2006 Dec 14. We have previously shown that the inhibitory neuromodulator attenuates the release of preloaded D-[3H] from murine corticostriatal slices evoked by ischemic conditions or by application of the sodium channel agonist veratridine. The glycine receptor antagonist strychnine and the (A) receptor antagonist bicuculline did not block the effect, although picrotoxin, a less specific blocker of agonist-gated channels, completely prevented the effect of on veratridine-induced D-[3H] release. |
1(0,0,0,1) | Details |
| 10718754 | Bloomfield SA, Xin D: Surround inhibition of mammalian AII amacrine cells is generated in the proximal retina. J Physiol. 2000 Mar 15;523 Pt 3:771-83. Application of the antagonist, strychnine, had only minor and variable effects on AII cell responses. Application of the voltage-gated sodium channel blocker TTX enhanced the on-centre responses of AII cells but attenuated or abolished their off-surround responses. 7. |
1(0,0,0,1) | Details |
| 16611622 | Stehr CM, Linbo TL, Incardona JP, Scholz NL: The developmental neurotoxicity of fipronil: notochord degeneration and locomotor defects in zebrafish embryos and larvae. Toxicol Sci. 2006 Jul;92(1):270-8. Epub 2006 Apr 12. Moreover, the degenerative effects of fipronil (1.1 microM) were reversed by coexposure to the sodium channel blocker MS-222 (0.6mM). The notochord effects of fipronil were phenocopied by exposure to 70 microM strychnine, a glycinergic receptor antagonist. |
1(0,0,0,1) | Details |
| 8867247 | Nagy I, Woolf CJ: Lignocaine selectively reduces C fibre-evoked neuronal activity in rat spinal cord in vitro by decreasing and neurokinin receptor-mediated post-synaptic depolarizations; implications for the development of novel centrally acting analgesics. Pain. 1996 Jan;64(1):59-70. This includes a reduction of direct or synaptically driven - and NK receptor-mediated post-synaptic depolarizations indicating that this class of sodium channel blockers may be potentially useful as analgesic agents, possibly acting on TTX-resistant channels. Application of the opiate, GABAA and GABAB receptor antagonists, naloxone (1 microM), strychnine (100 microM), bicuculline (100 microM) and phaclofen (100 microM) did not alter the depressant effects of lignocaine on the VRP. |
1(0,0,0,1) | Details |
| 16781687 | Molchanova SM, Oja SS, Saransaari P: attenuates D-[3H] release evoked by depolarization in ischemic corticostriatal slices. Brain Res. 2006 Jul 12;1099(1):64-72. Epub 2006 Jun 15. However, it suppressed the synaptic release of D-[(3) H] evoked by the voltage-gated sodium channel opener veratridine (0.1 mM). The uptake inhibitor (5 mM), the glycine receptor antagonist strychnine (0.1 mM) and the (A) receptor antagonist bicuculline (0.1 mM) did not block the effect. |
1(0,0,0,1) | Details |
| 16760346 | Harvey PJ, Li X, Li Y, Bennett DJ: Endogenous monoamine receptor activation is essential for enabling persistent currents and repetitive firing in rat spinal motoneurons. J Neurophysiol. 2006 Sep;96(3):1171-86. Epub 2006 Jun 7. However, the spike evoked after a slow ramp depolarization was slightly reduced in height and rate-of-rise, suggesting decreased sodium channel availability as a result of increased channel inactivation. |
2(0,0,0,2) | Details |
| 16690214 | Shao M, Hirsch JC, Peusner KD: Maturation of firing pattern in chick vestibular nucleus neurons. . Neuroscience. 2006 Aug 25;141(2):711-26. Epub 2006 May 11. At hatching day 5, a persistent sodium channel was essential for the generation of spontaneous spike activity, while a small conductance, -dependent current modulated both the spontaneous and evoked spike firing activity. |
1(0,0,0,1) | Details |