| Name | lactate dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | LDH; lactate dehydrogenase; lactate dehydrogenases |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10673068 | Frank A, Rauen U, de Groot H: Protection by against hypoxic injury of rat hepatocytes: inhibition of ion fluxes through nonspecific leaks. J Hepatol. 2000 Jan;32(1):58-66. Loss of viability was determined by release of lactate dehydrogenase. |
1(0,0,0,1) | Details |
| 20237771 | Silva MR, Ximenes RM, da Costa JG, Leal LK, de Lopes AA, de Barros Viana GS: Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf. in mice. Naunyn Schmiedebergs Arch Pharmacol. 2010 Mar 17. The objective of the present study was then to study, in a comparative way, the effects of both EOs on three models of convulsions (pentylenetetrazol, pilocarpine, and strychnine) and on the barbiturate-induced sleeping time on male Swiss mice. Furthermore, the in vitro effects of the EOs were also studied on myeloperoxidase (MPO; a biomarker for inflammation) and lactate dehydrogenase (LDH; an index of cytotoxicity) releases from human neutrophils. |
1(0,0,0,1) | Details |
| 20186763 | Wang GH, Jiang ZL, Chen ZQ, Li X, Peng LL: Neuroprotective effect of against temporary cerebral ischemia in rats. J Neurosci Res. 2010 Feb 22. dose-dependently decreased the neurology deficit score and infarct volume, elevated the cell viability and inhibited the leakage of lactate dehydrogenase. These effects were blocked by strychnine in both MCAO rats and cultured hippocampal neurons. |
1(0,0,0,1) | Details |
| 9572287 | Pearlstein RD, Beirne JP, Massey GW, Warner DS: Neuroprotective effects of NMDA receptor recognition site antagonism: dependence on concentration. J Neurochem. 1998 May;70(5):2012-9. The effects of and ACEA 1021 on -induced LDH release were consistent with a model of simple competitive interaction for the strychnine-insensitive NMDA receptor recognition site, although nonspecific effects at the kainate receptor may be of lesser importance. |
0(0,0,0,0) | Details |
| 15836436 | Pan C, Bai X, Fan L, Ji Y, Li X, Chen Q: Cytoprotection by against ATP-depletion-induced injury is mediated by glycine receptor in renal cells. Biochem J. 2005 Sep 1;390(Pt 2):447-53. Furthermore, the mutation of Tyr202 to in GlyRa1 blocked the -mediated cytoprotection, while the mutation of Tyr202 to abolished the cytoprotection by strychnine. |
0(0,0,0,0) | Details |
| 11238050 | Dong Z, Venkatachalam MA, Weinberg JM, Saikumar P, Patel Y: Protection of ATP-depleted cells by impermeant strychnine derivatives: implications for cytoprotection. Am J Pathol. 2001 Mar;158(3):1021-8. In an injury model of Madin-Darby canine kidney cells, ATP depletion led to lactate dehydrogenase release. |
2(0,0,0,2) | Details |