Protein Information

Name vascular endothelial growth factor
Synonyms VEGF; VEGF A; VEGFA; VPF; Vascular endothelial growth factor A; Vascular endothelial growth factor A precursor; Vascular permeability factor; vascular endothelial growth factor…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
10960447 Zhang Y, Ikejima K, Honda H, Kitamura T, Takei Y, Sato N: Glycine prevents apoptosis of rat sinusoidal endothelial cells caused by deprivation of vascular endothelial growth factor. Hepatology. 2000 Sep;32(3):542-6.

Furthermore, strychnine (1 micromol/L), a glycine receptor antagonist, inhibited this effect of glycine, suggesting the possible involvement of the glycine receptor/chloride channel in the mechanism.
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17567469 Yamashina S, Ikejima K, Rusyn I, Sato N: Glycine as a potent anti-angiogenic nutrient for tumor growth. J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1:S62-4.

Further, the inhibitory effects of glycine were prevented by low concentrations of strychnine (1 micromol/L) or incubation with chloride-free buffer.
Vascular endothelial growth factor (VEGF) plays a critical role in cancer progression by promoting new blood vessel formation.
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11962256 Yamashina S, Konno A, Wheeler MD, Rusyn I, Rusyn EV, Cox AD, Thurman RG: Endothelial cells contain a glycine-gated chloride channel. . Nutr Cancer. 2001;40(2):197-204.

First, the effects of glycine on vascular endothelial growth factor-induced increases in intracellular Ca2+ concentration in a bovine endothelial (CPA) cell line were studied.
Furthermore, the inhibitory effects of glycine were prevented by 1 microM strychnine, a glycine receptor antagonist, or when cells were incubated in Cl (-)-free buffer.
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