| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | 2,4,5-T |
|---|---|
| CAS | 2-(2,4,5-trichlorophenoxy)acetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3365825 | Bacher MA, Gibson GG: Chlorophenoxyacid herbicides induce microsomal cytochrome P-450 IVA1 (P-452) in rat liver. Chem Biol Interact. 1988;65(2):145-56. Liver microsomes from rats orally treated with the herbicides at 3 dose levels showed a significant increase in total cytochrome P-450 content with 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) being the most potent inducer. |
9(0,0,1,4) | Details |
| 6141874 | Iscan M, Arinc E, Vural N, Iscan MY: In vivo effects of 3-methylcholanthrene, phenobarbital, pyrethrum and 2,4,5-T isooctylester on liver, lung and kidney microsomal mixed-function oxidase system of guinea-pig: a comparative study. Comp Biochem Physiol C. 1984;77(1):177-90. Cytochrome P-450 content of guinea-pig liver microsomes were increased significantly about 2.5-fold and 2-fold by treatment with 3-methylcholanthrene and phenobarbital, respectively. 3-Methylcholanthrene also caused 1 nm spectral shift in the absorption maxima of CO difference spectrum of the dithionite-reduced liver microsomal cytochrome P-450, forming P-449. |
1(0,0,0,1) | Details |
| 10918358 | Kaya B, Creus A, Yanikoglu A, Cabre O, Marcos R: Use of the Drosophila wing spot test in the genotoxicity testing of different herbicides. Environ Mol Mutagen. 2000;36(1):40-6. Four herbicides, namely propanil, maleic hydrazide, and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), were investigated for genotoxicity in the wing spot test of Drosophila melanogaster. The HB cross uses flies characterized by an increased cytochrome P-450-dependent bioactivation capacity, which permits a more efficient biotransformation of promutagens and procarcinogens. |
1(0,0,0,1) | Details |