| Name | benzodiazepine receptor (protein family or complex) |
|---|---|
| Synonyms | Benzodiazepine receptor; benzodiazepine (BDZ) receptor; BDZ receptor |
| Name | piperazine |
|---|---|
| CAS | piperazine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18446327 | de Bortoli VC, Nogueira RL, Zangrossi H Jr: Alprazolam potentiates the antiaversive effect induced by the activation of 5-HT (1A) and 5-HT (2A) receptors in the rat dorsal periaqueductal gray. Psychopharmacology. 2008 Jun;198(3):341-9. Epub 2008 Apr 30. MATERIALS AND METHODS: Male Wistar rats, subchronically (3-6 days) or chronically (14-17 days) treated with alprazolam (2 and 4 mg/kg, i.p.) were intra-DPAG injected with (+/-)-8--2-(di-n-propylamino) tetralin hydrobromide (8-OH-DPAT), (+/-)-1-(2,5-dimethoxy-4-iodophenyl) piperazine dihydrochloride (DOI), and midazolam, respectively, 5-HT (1A), 5-HT (2A/2C), and benzodiazepine receptor agonists. |
32(0,1,1,2) | Details |
| 12809949 | Wesolowska A, Paluchowska M, Chojnacka-Wojcik E: Involvement of presynaptic 5-HT (1A) and benzodiazepine receptors in the anticonflict activity of 5-HT (1A) receptor antagonists. Eur J Pharmacol. 2003 Jun 13;471(1):27-34. In the present paper, we examined the effect of lesions of neurons, produced by p-chloroamphetamine (p-CA; 2 x 10 mg/kg), and the influence of flumazenil (Ro 15-1788, 10 mg/kg), a benzodiazepine receptor antagonist, on the anticonflict activity of N-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-N-(2-pyridinyl) cyclohexanec arboxamide (WAY 100635) and trans-1-(2-methoxy-phenyl)-4-[4-succinimidocyclohexyl] piperazine (MP 349), pre- and postsynaptic 5-HT (1A) receptor antagonists, and 1-(2-methoxyphenyl)-4-(4-succinimidobutyl) piperazine (MM 77), a postsynaptic 5-HT (1A) receptor antagonist, in the Vogel conflict drinking test in rats. |
31(0,1,1,1) | Details |
| 15916857 | Abrams JK, Johnson PL, Hay-Schmidt A, Mikkelsen JD, Shekhar A, Lowry CA: Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs. Neuroscience. 2005;133(4):983-97. Anxiogenic drugs with diverse pharmacological properties including the receptor antagonist the 5-HT2A/2C receptor agonist m-chlorophenyl piperazine (mCPP), the alpha2-adrenoreceptor antagonist yohimbine, and the benzodiazepine receptor partial inverse agonist N-methyl-beta-carboline-3-carboxamide (FG-7142) induced increases in behavioral arousal and vigilance behaviors consistent with an increase in anxiety state. |
81(1,1,1,1) | Details |
| 18510350 | Cappelli A, Mancini A, Sudati F, Valenti S, Anzini M, Belloli S, Moresco RM, Matarrese M, Vaghi M, Fabro A, Fazio F, Vomero S: Synthesis and biological characterization of novel 2-quinolinecarboxamide ligands of the peripheral benzodiazepine receptors bearing technetium-99m or rhenium. Bioconjug Chem. 2008 Jun;19(6):1143-53. Epub 2008 May 30. Potential receptor imaging agents based on Tc-99m for the in vivo visualization of the peripheral benzodiazepine receptor (PBR) have been designed on the basis of the information provided by the previously published structure-affinity relationship studies, which suggested the existence of tolerance to voluminous substituents in the receptor area interacting with 3-position of the quinoline nucleus of 2-quinolinecarboxamides 5. In the first step of the investigation, the stereoelectronic features of the above-indicated receptor area were also probed by means of 4-phenyl-3-[(1-piperazinyl) methyl]-2-quinolinecarboxamide derivatives bearing different substituents on the terminal piperazine atom (compounds 6a-f). |
1(0,0,0,1) | Details |
| 16396744 | Koros E, Bienkowski P, Kostowski W: Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on discrimination in the rat. Alcohol. 2005 Jun;36(2):107-15. In substitution tests, diazepam (0.5-2.5 mg/kg), a nonselective benzodiazepine receptor agonist, partially generalized from the cue in both groups. |
1(0,0,0,1) | Details |