| Name | 11 beta hydroxysteroid dehydrogenase type 2 |
|---|---|
| Synonyms | 11 beta HSD; HSD2; 11 beta hydroxysteroid dehydrogenase type 2; 11 DH2; 11 beta HSD2; AME; AME 1; AME1… |
| Name | thiram |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16857225 | Garbrecht MR, Krozowski ZS, Snyder JM, Schmidt TJ: Reduction of glucocorticoid receptor ligand binding by the 11-beta hydroxysteroid dehydrogenase type 2 inhibitor, Thiram. Steroids. 2006 Oct;71(10):895-901. Epub 2006 Jul 18. Thiram (tetramethylthiuram disulfide) specifically inhibits HSD2 activity by oxidizing residues located in the cofactor binding domain of the enzyme. |
201(2,3,4,6) | Details |
| 12901862 | Atanasov AG, Tam S, Rocken JM, Baker ME, Odermatt A: Inhibition of 11 beta-hydroxysteroid dehydrogenase type 2 by dithiocarbamates. Biochem Biophys Res Commun. 2003 Aug 22;308(2):257-62. The sulfhydryl protecting reagent blocked thiram-induced inhibition and NAD+ partially protected 11 beta-HSD2 activity, indicating that DTCs act at the cofactor-binding site. |
114(1,2,2,4) | Details |